St. John's Wort is relatively popular, as it has a reputation as a natural alternative to prescription antidepressants, but I think a lot of people give up on it because it never takes effect. Here is some evidence that shows that all but the supercritical version are useless:
"Hyperforin contents of the methanolic and C02-extracts were 1.5 and 38.8% respectively."
Müller, W. E., Singer, A., Wonnemann, M., Hafner, U., Rolli, M., & Schäfer, C. 1998. Hyperforin represents the neurotransmitter reuptake inhibiting constituent of hypericum extract. Pharmacopsychiatry, 31(S1), 16–21. doi: 10.1055/s-2007-979341 Extracts and chemicals, page 18
"Hyperforin contents of the methanolic and C02-extracts were 1.5 and 38.8% respectively."
Müller, W. E., Singer, A., Wonnemann, M., Hafner, U., Rolli, M., & Schäfer, C. 1998. Hyperforin represents the neurotransmitter reuptake inhibiting constituent of hypericum extract. Pharmacopsychiatry, 31(S1), 16–21. doi: 10.1055/s-2007-979341 Extracts and chemicals, page 18
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