Observant
Nothing Stops The Void
I recently aquired some of this stuff , quite a lot aqtually - I had 2 latenight trials with doses around 200mg and noticed a definite effect. Its hard to describe (No Skin-Flushing) . Has anyone experience with this? It sounded to me like an interesting supplement and trip aid especially with LSA/LSH ("most psychedelics are vasoconstrictors" )
en.wikipedia.org
Please have a look its relatively small amount of information that i could find on the net:
It sounds like interesting stuff but then... not many sources of experience reports.
Do you think one can get hypervitaminosis from the Niacin if used as regular medication?
Observant


Picamilon - Wikipedia
Please have a look its relatively small amount of information that i could find on the net:
wiki said:Picamilon (also known as nicotinoyl-GABAm Pycamilon, Pikamilon, etc) is a dietary supplement formed by combining niacin with GABA. It was developed in the Soviet Union in 1969 by the All-Union Vitamins Scientific Research Institute[1][2] and further studied in both Russia[3] and Japan as a prodrug of GABA.[4]
Picamilon is sold in the United States as a dietary supplement, while in Russia it is sold over the counter. The rights to the drug belong to pharmaceutical company NPK EKhO ("НПК ЭХО"), Moscow, Russia.
Contents
[hide]
* 1 Mechanism of action and potential therapeutic applications
* 2 Medical use in Russia
* 3 References
* 4 External links
[edit] Mechanism of action and potential therapeutic applications
Picamilon is able to cross the blood-brain barrier[5] and then is hydrolyzed into GABA and niacin. The released GABA in theory would activate GABA receptors potentially producing an anxiolytic response.[6] The second released component, niacin acts as a strong vasodilator,[7] which might be useful for the treatment of migraine headaches.[8][9]
[edit] Medical use in Russia
In Russia, Picamilon is used for treatment of these illness.[10]
1. Violations of cerebral blood flow (ischemic acute, subacute and rehabilitation period of ischemic stroke, chronic insufficiency of cerebral blood flow);
2. Vasoneurosis;
3. Asthenia;
4. Depression;
5. Senile psychosis;
6. Alcohol (period of abstinence), acute alcohol intoxication;
7. Migraine
8. Craniocerebral trauma
9. Neuroinfections;
10. Primary open-angle glaucoma (for stabilization of visual function).
dosage advice from a supplier said:50mg-100mg one to three times daily - according to individual needs with a big glass of water
It sounds like interesting stuff but then... not many sources of experience reports.
Do you think one can get hypervitaminosis from the Niacin if used as regular medication?
