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psilocybin extraction/tincture tek

Bump*


I'll ask again, but simply:

What to do with a glass full of ethanol which has been soaking finely cut, fresh
mushrooms & filtered through a cotton filter?

Do I evaporate it down to obtain a crude smokable extract?
Could I change the PH of the ethanol so that the goodies will
precipitate out of solution? Or could I best do something else with it?
 
So I have a little ball of mushroom extract that, forgive the comparison, looks like black tar heroin. My friend gave it to me about a year ago and i still haven't tried it. I always thought that it must've been an alcohol extract but it seems like that would normally yield a white or green product right? She said it was some kind of cold water extraction but I didn't believe her and neither did she really.

Anyone have any idea what kind of extraction would yield a black ball? It was about the size of a jolly rancher and supposed to be equivalent to an oz of the mushies extracted
 
I did my extraction using methanol and came up with stuff resembling what your talking about.

From what I can tell from reading, I have a ball of: psilocybin, psilocin, and assorted sugars and starches. But no chitin! And that make my tummy happy. :)
 
SKA said:
Bump*


I'll ask again, but simply:

What to do with a glass full of ethanol which has been soaking finely cut, fresh
mushrooms & filtered through a cotton filter?

Do I evaporate it down to obtain a crude smokable extract?
Could I change the PH of the ethanol so that the goodies will
precipitate out of solution? Or could I best do something else with it?
Click to expand...

I know that getting FB psilicybin/psilocin is a tricky feat and FB is what you'd need to vape. The chemistry experts should weigh in on that. The first few pages of this thread explain some of those difficulties.

If it were me? I'd dry it out and eat it. Or even just drink it since it's ethanol. Maybe in a little OJ. That's a Psilly Screwdriver :)
 
Luuk said:
Throw some diluted ammonia on there?
Click to expand...

It's not Meth :p Even if that DID work... I'd much
prefer not to use ammonia in anything I intend to smoalk.

So is there anyone here who would know how to turn an impure,
ethanolic psilocin/psilocybin extract of mushrooms into FB?
Someone said it was tricky to turn Psilocin into Freebase...
So how hard is it really? Can it be done using Kitchen chemistry?

Anyone? I can't believe making FB Psilocin from mushroom extracts
& smoalking that is as poorly explored as it is.
 
Luuk said:
Throw some diluted ammonia on there?
Click to expand...
I dont know much about psilocybin, but this works freebasing many amine alkaloids, so it would probably work with psilocybin. Ammonia is really not all that evil SKA, as it is very volatile and evaporates cleanly. I know benzyme mentioned psilocybin has 4 pka's though, so not entirely sure.
 
SKA said:
Luuk said:
Throw some diluted ammonia on there?
Click to expand...

It's not Meth :p Even if that DID work... I'd much
prefer not to use ammonia in anything I intend to smoalk.

So is there anyone here who would know how to turn an impure,
ethanolic psilocin/psilocybin extract of mushrooms into FB?
Someone said it was tricky to turn Psilocin into Freebase...
So how hard is it really? Can it be done using Kitchen chemistry?

Anyone? I can't believe making FB Psilocin from mushroom extracts
& smoalking that is as poorly explored as it is.
Click to expand...

that sort of limited view of chemistry won't accomplish anything.
you won't convert psilocybin to a free base using sunshine and good karma.

people use lime in their DMT teks, which is also used to make cocaine base..but you don't tell them "it's not coke".
 
i've still always been of the opinion that the best low budget kitchen psilocin/cybin tek would be to do a warm 70% methanol extract that you evaporate under vacuum, then dissolve the resulting goo/xtals into water which you dilute with ethanol and put into a dropper vial, tincture styles.

:thumb_up:
 
Shadowman-x said:
i've still always been of the opinion that the best low budget kitchen psilocin/cybin tek would be to do a warm 70% methanol extract that you evaporate under vacuum, then dissolve the resulting goo/xtals into water which you dilute with ethanol and put into a dropper vial, tincture styles.

:thumb_up:
Click to expand...
Yes, this is pretty much as far as one can go with psilocybin extraction in a kitchen environment....
 
Infundibulum said:
Shadowman-x said:
i've still always been of the opinion that the best low budget kitchen psilocin/cybin tek would be to do a warm 70% methanol extract that you evaporate under vacuum, then dissolve the resulting goo/xtals into water which you dilute with ethanol and put into a dropper vial, tincture styles.

:thumb_up:
Click to expand...
Yes, this is pretty much as far as one can go with psilocybin extraction in a kitchen environment....
Click to expand...
YEAH, now I have endorsement from Inf AND ben that this is the most reasonable way.
MY SCIENCE FU IS IMPROVING :love:
 
benzyme said:
SKA said:
Luuk said:
Throw some diluted ammonia on there?
Click to expand...

It's not Meth :p Even if that DID work... I'd much
prefer not to use ammonia in anything I intend to smoalk.

So is there anyone here who would know how to turn an impure,
ethanolic psilocin/psilocybin extract of mushrooms into FB?
Someone said it was tricky to turn Psilocin into Freebase...
So how hard is it really? Can it be done using Kitchen chemistry?

Anyone? I can't believe making FB Psilocin from mushroom extracts
& smoalking that is as poorly explored as it is.
Click to expand...

that sort of limited view of chemistry won't accomplish anything.
you won't convert psilocybin to a free base using sunshine and good karma.

people use lime in their DMT teks, which is also used to make cocaine base..but you don't tell them "it's not coke".
Click to expand...

Sorry, we don't all have extensive chemistry knowledge like you.
Being a chem noob I was just worried about potential residues of
ammonia in my final product. I thought since ammonia is known to
be rather agressive on the lungs I figured it'd be the sort of
thing you don't want mixed with something you intend to smoalk.

I'm concerned about my health & I know very little of chemistry.
If I could use lime to freebase 4-HO-DMT I'd prefer that as it
would be safer to evaporate & inhale than ammonia I intuited...

And why so cynical? My "meth"-remark was dumb but innocent.
You seem agitated while I'm just trying to learn.
Do I strike you as someone who thinks karma & sunlight will do
the trick? Rather a condescending & uncalled for thing to say.:?:



So could lime freebase Psilocin? And if this can be done safely with Ammonia, how?
I would very much like to smoalk freebase 4-HO-DMT.
 
I don't know if either of the two will simply work because of the multiple pKa's of psilocybin, you could need a specific pH. Maybe someone else can chime in? However they both work for freebasing alkaloids. Ammonia is volatile so all unreacted ammonia will vaporize, it is easy to check if all ammonia is gone because of it's strong smell. Lime will not vaporize, so if you use lime you need to dry your freebased extract and then pull the freebase psilocybin with a solvent ( I guess all alcohols would work?). Because psilocybin is rather unstable I would avoid very high pH. This is why when using ammonia I would dilute it enough.

Does anyone know something about required/recommended pH values for freebasing psilocybin?
 
Luuk said:
Does anyone know something about required/recommended pH values for freebasing psilocybin?
Click to expand...
Psilocybin cannot exactly be "freebased", but its isoelectric point i.e. the pH where the molecule has an overall neutral charge (which is the closest you can get to the definition of "freebase" was calculated to around pH=4 by Benzyme.

Psilocin can be freebased at basic pH values, but prolonged exposure to pH more than 9 will degrade psilocin. And you need a pH of at least 10 to have ~97% of psilocin freebased. And the more you're evaporating a basic solution with freebased psilocin the more the pH will be rising (as the concentration of base will be increasing relative to the evaporating water) further promoting degradation of psilocin. On top of that, in dried mushrooms samples psilocin is almost non-existent, so you have to devise an efficient way of dephosphorylating psilocybin to psilocin AND as well monitor the conversion before you go on to the freebasing step....

All in all, the path to freebase psilocin is thorny to say the least. I'd be very interested to hear, as jamie said how nen did it and what the experience of vaporising FB psilocin was like.
 
I thought that psilocybin was converted to psilocin upon crossing the blood-brain barrier, anyway. Is that outdated information?

If it's true, is there something standing in the way of smoking psilocybin? It seems like a more likely candidate due to its stability.
 
psilocybin is dephosphorylated through hydrolysis, which occurs much faster at low pH, like in your stomach.

I attempted to vaporize a methanolic mushroom extract before, It was certainly active, but i also felt it was wasteful, so I did not pursue it, and I continued to eat the rest of it instead.

Definitely something worth pursuing, but as others have stated its not as simple as "FB PSILOCIN"
 
Mr.Peabody said:
I thought that psilocybin was converted to psilocin upon crossing the blood-brain barrier, anyway. Is that outdated information?

If it's true, is there something standing in the way of smoking psilocybin? It seems like a more likely candidate due to its stability.
Click to expand...
Dephosphorylation of psilocybin is required for the resulting psilocin to cross the blood-brain-barrier and exert its effects in teh mind. Dephosphorylation happens somewhere in body, which can be the stomach with its low pH as Mindlusion said and/or other places, maybe liver? blood? etc.

So it is wrong to think that by smoking psilocybin you can get psilocin effects. Our knowledge so far points that one needs to smoke FB psilocin for effects.

Mindlusion said:
psilocybin is dephosphorylated through hydrolysis, which occurs much faster at low pH, like in your stomach.
Click to expand...
Yes, acid seems to be a crucial catalyst for the dephosphorylation. I once tried to extract psilocin from the psilocybin-high containing p.semilanceatas adding a dephosphorylation step as per the usual method (soak the dried mushroom mass in water making sure final pH is adjusted to 4 using acetic acid, let in room temperature 1h, then heat up at 70 C for 10min, chilled and filter out the pieces) but I got nothing after the basifying @ pH=9 and pulling with dcm...

We should not forget that it is still debatable whether psilocybin dephosphorylation is caused by low pH alone and/or whether mushroom enzymes play an important part in the process. Is there anyone that has demonstrated that pure psilocybin (not aqueous mushroom extract) can dephosphorylate by acid alone?
 
Infundibulum said:
We should not forget that it is still debatable whether psilocybin dephosphorylation is caused by low pH alone and/or whether mushroom enzymes play an important part in the process. Is there anyone that has demonstrated that pure psilocybin (not aqueous mushroom extract) can dephosphorylate by acid alone?
Click to expand...

This is an extremely good question. This needs to be explored.

Endlessness has had the opportunity to run these kind of experiments with a mass spec in the the past..

Whoever is doing spectro analysis at this time should have this on their list. Something is going on that we are unaware of
 
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