Elrik
Rising Star
Its almost time to extract more harmalas and I'm curious if any practical method has been devised for removal of harmane from harmine?
By practical I mean not flash chromatography or vacuum sublimation
They seem to have nearly identical pKa's, from the literature it seems harmaneā¢HCl will 'manske' out with excess chloride ions the way harmineā¢HCl does, I'm not seeing any clear indication of harmanes solubility in toluene but it will crystallize from hot heptane. Its listed as soluble to the extent of 50 mg/ml in methanol, that might be a clue.
I'd like to try harmane-free harmine, but my only viable Ć-carboline source is P. harmala.
By practical I mean not flash chromatography or vacuum sublimation

They seem to have nearly identical pKa's, from the literature it seems harmaneā¢HCl will 'manske' out with excess chloride ions the way harmineā¢HCl does, I'm not seeing any clear indication of harmanes solubility in toluene but it will crystallize from hot heptane. Its listed as soluble to the extent of 50 mg/ml in methanol, that might be a clue.
I'd like to try harmane-free harmine, but my only viable Ć-carboline source is P. harmala.