downwardsfromzero
Boundary condition
Never underestimate the power of grapefruit juice. It has killed in combination with (now discontinued) OTC antihistamine terfenadine to name but one.PsyDuckmonkey said:Applying Occam's razor, that wasn't MDMA. The grapefruit juice had nothing to do with this.
Know that MDMA is the most routinely adulterated and counterfeited drug on the market. At this time I wouldn't put any amphetamine derivative in my body without at least checking it with a three-point test kit. Either get your MDMA from medical sources, or get a three-point test kit (google "Bunk police").
An overdose of meth is a possibility, but it could have been anything, really, including a mixture of multiple "anythings".
Inhibition of the CYP3A4 enzyme is irreversible and lasts a significant period of time. It takes around 24 hours to regain 50% of the enzyme activity and it can take 72 hours for the enzyme to completely return to activity.
grapefruit contains a large amount of naringin, and it can take up to 72 hours before the effects of the naringin on the CYP3A4 enzyme are seen. This is problematic as a 4 oz portion of grapefruit contains enough naringin to inhibit the metabolism of substrates of CYP3A4.
Enzyme inhibitors + unknown euphoriant stimulant(s)
I'm glad you survived and await news of the reagent tests.