Several 25x-NBOMe Compounds Scheduled in the US as of 11/15/13

[Entheogenerator]

I am aware that discussion of novel psychoactive substances or research chemicals is, for the most part, discouraged on The Nexus. But I didn't see any topics on the forum addressing this new information, so I figured I would share this. I stumbled across this short article on NeuroSoup.com (a fantastic informational/ harm reduction site on the subject of psychoactive substances, for those of you who are not familiar with the site), and I figured there might be a few people on The Nexus who could benefit from this information. I do not have much interest in most of these novel psychoactive substances, but I know that there are a significant number of Nexus members who have expressed more interest in them than I.

http://www.neurosoup.com/25i-nbome-25c-nbome-and-25b-nbome-are-now-illegal-in-the-u-s/

As of November 15 , 2013, the United States Drug Enforcement Administration (DEA) made the synthetic phenethylamines 25I-NBOMe, 25C-NBOMe, and 25B-NBOMe illegal drugs under the Controlled Substances Act (CSA). These three NBOMe’s will be listed as Schedule I for the next two years. These drugs are marketed online and through illicit channels as illicit hallucinogens such as LSD. They have been encountered as powders, oral liquid drops, nose drops, soaked onto blotter paper, and absorbed within edible items.

The actual chemical names of today’s controlled synthetic drugs are:
2-(4-iodo-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine (25I-NBOMe);
2-(4-chloro-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine (25C-NBOMe); and
2-(4-bromo-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine (25B-NBOMe).

There is no approved medical use for these particular synthetic drugs, nor has the Food and Drug Administration approved them for human consumption. No published studies exist on their safety for human use. The NBOMe compounds are substantially more potent than other hallucinogenic compounds, and the data suggest that extremely small amounts of these drugs can cause seizures, cardiac and respiratory arrest, and death. In fact, these NBOMe’s have been linked to the deaths of at least 19 Americans aged 15 to 29 between March of 2012 and August of 2013. Additionally, synthetic drugs like these have no consistent manufacturing and packaging processes and may contain drastically differing dosage amounts, a mix of several drugs, and unknown adulterants.

According to a recent DEA press release, this action is based on a finding by DEA Deputy Administrator Thomas Harrigan that the placement of these synthetic drugs into Schedule I of the CSA is necessary to avoid an imminent hazard to public safety. The DEA published a Notice of Intent to do this on October 10, giving makers, sellers, and other possessors of these drugs a month to rid themselves of their current stocks and to cease making or buying more. During the next two years, DEA will work with the U.S. Department of Health and Human Services to determine if these drugs should be made permanently illegal.

Personally, I think it is a little absurd for governments to think that they are going to be able to outlaw every substance that has some potential to be used as a recreational drug (aside from alcohol and tobacco, of course). To me, the fact that they have been completely unable to keep up with the pace at which the number of these different novel substances in circulation has increased seems to be a pretty accurate representation of the efficacy of their methods. But the unwinnable war rages on.

 

[Entheogenerator]

Further confirmation of this, in case anyone does not find the above mentioned source to be reliable.

Erowid NBOMe Series Legal Status

 

[alert]

More official source if anyone wants to check it out.

Can't say I didn't see this one coming a million miles away. Ultrapotent psychedelics sold to anyone with a credit card often under the guise of being something else has a predicatable outcome.

 

[Nathanial.Dread]

What I find so infuriating about all this is that they are banning the NBOMEs because there's no consistent safety regulation, but the only reason that there is no safety regulation is because of the DEA!

It is the f*cking height of hypocrisy!

Blessings
~ND

 

[Orion]

Already happened in the UK, this was pretty much inevitable.

I wonder for how long these compounds will hang around in our cultural digestive system after the ban. Will people think it's worth it?

 

[Ufostrahlen]

What I wonder is the following: Is it possible to create a receptor binding profile (5-HT2A: 0,x nM etc.) of those banned molecules (NBOMEs, LSD, DMT etc.) and then design a new compound with molecular design software, which shares the receptor binding profile but not the analogue structure. For example a pharmacophore that triggers the same receptors like DMT, but which isn't a tryptamine. This should be perfectly legal, if it works.

 

[alert]

What I wonder is the following: Is it possible to create a receptor binding profile (5-HT2A: 0,x nM etc.) of those banned molecules (NBOMEs, LSD, DMT etc.) and then design a new compound with molecular design software, which shares the receptor binding profile but not the analogue structure. For example a pharmacophore that triggers the same receptors like DMT, but which isn't a tryptamine. This should be perfectly legal, if it works.

Assuming it wasn't an analog then yeah technically it would be legal. That doesn't mean the DEA wouldn't choose to schedule it anyway. It isn't only analogs that get scheduled...

 

[Ufostrahlen]

Assuming it wasn't an analog then yeah technically it would be legal. That doesn't mean the DEA wouldn't choose to schedule it anyway. It isn't only analogs that get scheduled...

Sure, but NBOMEs were developed ~ 2004 and are now banned 10 years later. If it takes the DEA 10 years from the development on to ban a substance, then there's plenty of time to (legally) test it.

 

[alert]

Assuming it wasn't an analog then yeah technically it would be legal. That doesn't mean the DEA wouldn't choose to schedule it anyway. It isn't only analogs that get scheduled...

Sure, but NBOMEs were developed ~ 2004 and are now banned 10 years later. If it takes the DEA 10 years from the development on to ban a substance, then there's plenty of time to (legally) test it.

The NBOMEs were originally developed ~2003/2004 but they didn't really hit the RC market until 2011. So really they were only available for about 2 years.

 

[Ufostrahlen]

Ah nice, research is already in progress:

Paulke, A., Kremer, C., Wunder, C., Achenbach, J., Djahanschiri, B., Elias, A., J. Schwed, S., Hübner, H., Gmeiner, P., Proschak, E., Toennes, S.W., Stark, H.
Argyreia nervosa (Burm. f.): Receptor profiling of Lysergic acid amide and other potential psychedelic LSD-like compounds by computational and binding assay approaches.
J. Ethnopharmacol. accepted

 

[Nathanial.Dread]

Alternatively, would it be possible for the Powers That Be to force through legislation banning any molecule that had a specific neurological effect?

Eg: "Any molecule that acts as a 5-HT2A agonist automatically will be treated like a Schedule 1 drug?"

That would be, to my mind, the most efficient way to kill all legal psychedelic research.

Blessings
~ND

 

[alert]

Alternatively, would it be possible for the Powers That Be to force through legislation banning any molecule that had a specific neurological effect?

Eg: "Any molecule that acts as a 5-HT2A agonist automatically will be treated like a Schedule 1 drug?"

That would be, to my mind, the most efficient way to kill all legal psychedelic research.

Blessings
~ND

I was reading a story about this a couple years ago regarding synthetic cannabinoids. I can't recall the state, but the local government there had a huge hatred towards these synthetics and whenever they would pass legislation people would just release new cannabinoids to get past the ban. They tried to draft legislation banning anything that worked as an agonist at the cannabinoid receptor, effectively a blanket ban. They ended up not passing the law, but I was reading analysis about it at the time people were questioning if such a ban would be shot down by the court, for example chocolate contains anandamide which and would fall under this ban making chocolate illegal.

 

[hixidom]

[tucking away last few 25I blotters]
On to the next big thing, I guess.