Sinomenine from Sinomenium Acutum

[PsilocybeChild]

I have read studies about it being a novel analgesic and evidence for it being an NMDA antagonist. Compare the molecule with dextromethopran. Could this possibly be a better analog of DXM for reaching those states?

A listing online for this states:

..3g+ sample of Sinomenium Acutum containing 99% pure Sinomenine. This is frequently used in TCM for it's purported pain relieving effects. I will add additional details in the near future. Feel free to reach out to me with any questions!

Here are two forum threads about it with no conclusions made:

https://drugs-forum.com/threads/sinomenine-natural-dissociative.294145/

Sinomenine - opiate or NMDA antagonist?

i ran across this little gem while web wandering.... Sinomenine or cocculine is an alkaloid found in the root of the climbing plant Sinomenium acutum which is native to Japan and China. It is traditionally used in herbal medicine in these countries, as a treatment for rheumatism and...

www.bluelight.org

Minor edit in quoted description. Sales lingo, etc.

 

[PsilocybeChild]

Dextromethorphan (DXM) molecule for comparison

 

[downwardsfromzero]

The geometry of sinomenine vs. that of DXM is rather different. Dashed bonds are below the plane of the picture. Wedge bonds project out of the plane. I've attached a side-by-side comparison of the two molecules and a 3-d rendering of each. Crucially, the nitrogen atom is positioned very differently in each respective case. I would predict that sinomenine displays neither an antitussive nor a dissociative effect, at least not at sensible doses.