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Solubility of harmala

Migrated topic.
mombreast

mombreast

Rising Star
Anyone knows of freebased harmala's solubility?
I tried to dissolve harmine and harmaline(both freebase) to
Acetone, Naphtha, Ethanol, Hot Ethanol, and DCM.
None seemed to work.

My harmalas are from manske.(thanks to endlessness's writeup)
It's brownish color, but plant material is thoroughly filtered out.
So i don't think this is because my harmalas are impure
and seeing plant material as undissolved thing.
But perhaps I'm wrong.

Anyone knows?
 
Thanks Crstalito, it looks quite scientific, it should be useful.

By the way could you mention epigramatically the steps you followed for the whole procedure?
Click to expand...
Extraction procedure? Sure, it went like this.
Seeds--> powder --> boil pH3.5 H2O -->boil down-->filter-->100celcius +NaCl
-->fridge-->filter-->pH8.75(harmine) -->pH12(harmaline)

One thing I did differently with the tek in the wiki, is that I skipped the recommended
repetitious masnke. I only did it twice. Instead, I washed the manske salt solution with
cold NaCl saturated water. Just pour off the solution leaving behind the salt, then pour in cold NaCl
water. This is an attempt to make it easier to filter. I repeated this over 5 times.
Then, the solution was filtered under vacuum. It run through 1um filter paper.

If Vasicinone and Vasicine does not dissolve in cold NaCl water, then manske shouldn't work,
it will precipitate and contaminate the final product. So...just washing the preciptate with cold NaCl water should
also get rid of the toxins. This is what I thought.

Why repetitious manske is recommended, if someone can explain, I will really appreciate.
 
I see, nice. I was curious about it and also i thought that it would be usefull to have here the method you followed so as to know exactly where you stand and also use it propably for "troubleshooting" purposes (for example there could have been something wrong in the method).

Also, keep this link at hand,it has lots of info on betacarboline properties: Erowid Online Books : "Ayahuasca: alkaloids, plants and analogs" by Keeper of the Trout

Now , on the "Manske" issue ("Hasenfratz" actually). Vascine and vascinone should not precipitate as you mentioned. While it might be easier to precipitate alkaloids with salt water and then do cold salt water washes "on the spot", this method might be of limited value because it washes the precipitate only superficialy. If one heats water to 100C and redissolves the precipitate in order to re-precipitate upon addition of salt, then even microcrystaline structures will dissolve freeing possible contaminants. Think of the crude precipitate as a "conglomerate" that the finer its broken down (dissolved, quite fine!) and re-precipitated, the more "junk" it will free to the water "up for grabs" and removal.

I do not know if this makes a PRACTICALL (read: noticable during a bioassay) difference, still though i follow it. It might be easier your way and not much different than a repeated manske, with the difference of course that your method seems way quicker.

The above pertain to my understanding of the procedures involved. If someone more knowledgable on the matter than me can chime in, it would be appreciated.
 
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