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Some fresh medical hypotheses on the roles of endogenous dmt

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Infundibulum

Infundibulum

Kalt und Heiß, Schwarz und Rot, Kürper und Geist,
Moderator
OG Pioneer
Chemical engineer
I just found this article few hours ago. It is a fresh review of the endogenous tryptamines story and somewhat similar to an earlier paper (Endogenous psychoactive tryptamines reconsidered: an anxiolytic role for dimethyltryptamine).

This one gives more focus on the trace amine receptors and it throws in some nice discussion both on potential interaction sites of the endogenous hallucinogens as well as putative affinities for the said substances and their receptors.

Sadly enough there are no data about the binding affinities of dmt, 5-meo-dmt and 5-HO-dmt on their newly discovered putative Trace Amine Receptors. Would make a nice future project though.
 

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I have read this paper over also. Very interesting paper. I don't know if the binding activity has been reported yet but I might have looked that up once, I will check through my literature sometime this week. I think I have found binding affinity for tryptamine and phenethylamine but can't remember.

I think its important that people read this to get a fresh view on the latest research to see that theres more to endogenous DMT then the pineal gland hypothesis, which I still see no evidence for.

Have the trace amine receptors been cloned? That could greatly facilitate research since they are membrane bound they need to be expressed in some liposome like membrane.
 
burnt said:
Have the trace amine receptors been cloned? That could greatly facilitate research since they are membrane bound they need to be expressed in some liposome like membrane.
Click to expand...
I really do not know but I'll look for that. It is fairly easy so someone must have done it. I can clone all of them and make culture cells to express them in a matter of 2-4 weeks if the gnomes of scientific adversity are not around. But I got no lab money to spend on such project.
 
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