Btw LSA contains an amide group, not an amine. I've found a few old papers on amide/aldehyde adducts but nothing on LSA specifically.
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Sprouting morning glory first?
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Btw LSA contains an amide group, not an amine. I've found a few old papers on amide/aldehyde adducts but nothing on LSA specifically.
Not sure he's actually going to do that...
I did some searching and found this mention of soma/kykeon from the "Oxford Centre for Hindu Studies" by a Dr Matthew Clark:
The ritual drink called soma/haoma, which can be traced to the late Bronze Age (c. 1600 BCE), is central to the religious practices of brahmans who perform Vedic ritual and also to Zoroastrianism. The three main theories currently endorsed by scholars are that soma/haoma was either fly-agaric mushrooms, ephedra or Syrian rue. The evidence seems to indicate that soma/haoma was a psychedelic/entheogenic drug of some kind (though not all scholars agree with this). I propose in my recent book (The Tawny One: Soma, Haoma and Ayahuasca, Muswell Hill Press, 2017) that soma/haoma was never a single plant but was instead a combination of plants that worked similarly to ayahuasca. I also propose that this kind of plant combination was most probably the basis of the ritual drink known as kykeon, which was used in Greek mystery rites.
In the literature I found this (also by Dr Matthew Clark):
Soma and Haoma: Ayahuasca analogues from the Late Bronze Age
- July 2019
- 3(2):1-13
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Good find - I've added it to the science paper section:
Investigating the psychedelic hypothesis of kykeon, the sacred elixir of the Eleusinian Mysteries - PMC
This study revisits the hypothesis that Claviceps purpurea (Fr.) Tul., a fungus infecting cereals and producing ergot alkaloids (EAs), was the psychedelic agent in kykeon, the sacred elixir of the Eleusinian Mysteries. Although archaeological ...
pmc.ncbi.nlm.nih.gov
This fact complicates the proposed synthesis even more complicated in my view.
Very interesting indeed. I was not aware of amide - aldehyde condensations altough I had been suspicious it might be possible. This mechanism make sense in the context of morning glory seeds which contains lysergic acid amide. There is the question of water. This is probably a reaction that is affected by equilibrium of the reactants, is that correct? Having a lot of water in the solution probably prevents the formation of the desired condensed product. Also there is the question of the pharmacological profile of these speculative compounds. If this has already beed discussed I apologize.
Yes, we must seriously consider if the rxn is occurring in-vivo... which makes sense when you consider that 2 things which Kash always mentions (peppermint, lemon juice) contain aldehyde dehydrogenase inhibitors (ALDHIs).
Downwardsfromzero also wrote about this possibility (of an in-vivo rxn) in his brandy experiment post.
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Yes, this was a typo mistake. I meant the amide group.
Can you link this post from mister DFZ?
Thanks for sharing this information. I was not even aware of these ALDH enzymes and the possibility of their inhibtion. Now the kash method seems to make much more sense.
EDIT: It seems I was aware of it before but had since forgoten about it or have never been creative enough to think about them in a context like this. Fascinating!
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I uncovered a few days ago that the Pennyroyal mint used in the Greek kykeon contains menthol, menthone and pulegone which all have ALDHI qualities. I'm willing to bet that this is relevant, and why Kash always highlighted peppermint in his posts.
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I think MG seeds contain many clavine alkaloids besides the lysergic ones. As an aside, I'm inclined to think (in agreement with what downwardsfromzero speculated many years ago) that any aldehyde rxn occurs in-vivo.
Identification and determination of ergot alkaloids in Morning Glory cultivars
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