Funnily enough when I heard they were making it I too had the idea and tried to design it and get in contact with people.
Because psychedelics are showing to be so incredibly efficacious and powerful, its very likely within the next 5 years it will all be legalized in the USA and other countries. Now, all this is not going on without FDA, NIH, and all the right safety precautions. So, there is a race in getting patents and research papers done for drug delivery systems, neuropsychopharmacology, cognition, analogs, and methods regarding DMT and psilocybin before it DOES become legal and society explodes. It's truly an exciting time for psychedelics and a time that will certainly redefine humanity's evolution into whatever we are about to get into these next few decades!
Now, this is the real kick in getting it made, which some of you might get antsy about but try to understand. You see, when you want to come out and say "hey, I want to get funded to try to get DMT/psilocybin on market or out there", you typically need to go through the NIH or FDA or an investment bank like FocalPoint and *pitch* the drug to
fulfill a clinical need. That way you can have a plan and draft scientific studies and get generate and prove hypotheses--get some data that demonstrates results by solving a problem (PTSD, depression, Parkinson's, ect.)
assuming you want to do a human study. Assume best possible results and we discover that short-15 minute DMT sessions are not good enough and long psilocybin sessions are too long for clinical therapy (which is where its going to be initially upon legalization). We are engineering the patch so that you can customize and readily adapt the trip's length, thereapuetic window (concentration of drug in blood plasma), terminate at will, and make an easy/safe time for the users/clincians. Product is good enough already and for people who want this device (which so far requires sophisticated equipment to manufacture none of us will get our hands on, because you can't 3D-print since its too high-resolution), you got to pay your dues to the patent holders. ALSO, you want this patch to deal with the big monster in the way:
insurance companies. That's right. A
real customer of this patch is insurance companies and, y'know, those guys that make the USA healthcare system insanely expensive. Why? Because in psychiatry and psychology, sessions are "paid by the hour"! So
if you can make a system where you can engineer the ideal trip that someone can do within an hour (so that they can get up and get out that office, but can't drive), with a series of sessions going through the weeks and months, you then satisfy the insurance companies who will proudly support your DMT patch. Note, I am sort of antagonizing them, but I do want to be fair... when we deal with trying to get people real, quality, therapy safely and robustly, there's a lot of work, people, and responsibilities. This ain't easy for anyone, and we can be thankful we have people who work their asses off to try to get things done. Yeah, some assholes cause a lot of shit, but if we believe we can make things better,
perhaps with a patch and drug of somekind, we can get things right.
When I made my first draft of my patch, I choose hollow silicone because it's ideal for large doses/delivers fast and silicone is hydrophobic so it can help saline-DMT slow down diffusion rate to "drip"--gives us a rough draft of an ideal profile. Then to make sure its right, you got to make a model of your mathematical model of differential equations.
I mean, its not a great resolution but you could say some shit like the infusion of DMT through a patch assuming thin slab geometry and Stokes Einstein...
dCin/dt = d/dx * [ release_rate_of_patch * ( (Boltzmann's_constant * Temperature) / (6 * pi * viscocity_of_DMT_through_dermis * radius_of_DMT_molecule) ) * dC/Dx ]
and then calculate the degradation of DMT in the body and then your task becomes something like, now that I know the degradation and parts of the infusion, what do I engineer or refine to get the release_rate_of_patch to be the right number so that I can reach and maintain a blood plasma DMT level of 60ng/mL for 6 hours!
LINK to figure: Good, M., et al., “Pharmacokinetics of N,N-dimethyltryptamine in Humans,” European Journal of Drug Metabolism and
Pharmacokinetics, vol. 48, pp. 311-327, 2023,
Pharmacokinetics of N,N-dimethyltryptamine in Humans - European Journal of Drug Metabolism and Pharmacokinetics
