Video about interesting (non-psychedelic?) Lysergamide analogue

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Some casual viewing for the more advanced chemist…

I've previously considered reconfigurations of the indole moiety relative to the rest of the molecule, but not this translocation of the indole nitrogen from the 1- to the 3-position.

 

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A google search for non-hallucinogenic psychedelic yields a ton of results about this territory.

Yes, it does!

non-hallucinogenic psychedelic at DuckDuckGo

DuckDuckGo. Privacy, Simplified.

www.duckduckgo.com

An LSD analogue for treating psychiatric diseases

Researchers designed a non-hallucinogenic analogue of LSD that had antidepressant and numerous cognitive benefits in mice.

www.nih.gov

Molecular design of a therapeutic LSD analogue with reduced hallucinogenic potential - PubMed

Decreased dendritic spine density in the cortex is a key pathological feature of neuropsychiatric diseases including depression, addiction, and schizophrenia (SCZ). Psychedelics possess a remarkable ability to promote cortical neuron growth and increase spine density; however, these compounds...

pubmed.ncbi.nlm.nih.gov

...specific to this compound. Ibogalog is covered in another thread, but there doesn't appear to be any mention of "iso-DMT" on the forum up to this point. Here's another relevant thread which resurfaced recently:

2-Br-LSD :: Non-hallucinogenic LSD analog with therapeutic potential

😁 "New study suggests that a non-hallucinogenic LSD analog may hold therapeutic potential for mood disorders." "Move over, Lucy in the sky with diamonds, there's a new non-hallucinogenic LSD in town. 2-Br-LSD is not your typical trip-inducing drug. Instead, it has a specific target in the...

forum.dmt-nexus.me

- where you mentioned JRT already, @bk2492
What would the 2-bromo analog of JRT do, I wonder?