What is going on neurologicaly in people who are immune to DMT? My friend doesnt feel DMT/Psilocybin

[n0thing]

I know how to vape properly and use both vapor genie/dab rig. It was pure spice and had frequently been used and tested. My friend was not on any medications whatsoever. I started him with:

20mg, no effect,
30mg, no effect,
50mg, no effect,
70mg, no effect,
100mg, no effect,
150mg, no effect.

As I kept loading it in I was trembling because I knew at that dose any ordinary person would lose there freakin' marbles if not pass out completely and felt totally irresponsible but he kept asking for more and yet still did not feel an absolute thing.

The next day I gave him some powdered harmalas along with many mushroom capsules. He took them and still did not feel anything. He also said he needs a lot of weed to get him high usually. He also has not recently taken any other psychedelics at all (or ever for that matter).

According to the Strassman study, 3 out of 60 people did not respond to IV DMT, that is 5%.

From this thread endlessness says:

I mean, maybe they have some weird genetics that means a lot more of some CYP or MAO enzymes that diminishes effects but , zero, at any dosage?? How is that physically possible?

Say if this was the case, would this mean that full MAOI inhibition might be reached not at 300mg but with something like 1g?

I feel this is an important issue, the 5% undermines all of our understanding of how this molecule acts upon our nervous systems.

 

[WisdomTooth]

Yeah the thing is he actually wants to experience something more like we experience but it never seems to effect him the same. I think he may get to a certain point then somehow prevent it going further possibly on a subconscious level truth he cannot accept yet? but could be conscious as well who knows.