I do not like yopo or in my case cebil very very much , the bufotenine in both raise my blood pressure it seems , which normally happens with my aya use anyway but it's more pronounced with my cebil seeds so I'll only use a couple with maois and add something else like viridis , or other bark , but I also do not like too many additives in general so on the rare occasion I do I try only a couple to a few tops , I have extracted crudely I may add , an extraction to add to maois but I just generally don't like that method of ingestion , if I have seed powder I have roasted and ground it is usually snuffed , I deal with the pain , for me ironically it isn't too bad, not sure why, I have sinus issues so maybe the blockage keeps the pain lower , dunno, many folks hate snuffing , however there are great tek s for extraction. I can vouche only for using and trying that roa once . It was worthwhile , but I normally have other projects so I would do that again only it's not a priority for me atm. There are benefits to bufotenine but I generally choose something else before it just bc of high blood pressure concerns on my part like I mentioned above. Those seeds are potent though so becareful, big difference between a few seeds and nine or ten , and their small size is deceiving. However some folks have had weak seeds, that s never been my case . Still some degree of nausea with snuffing too, just seems to be a part of it, someone else here may have a better way to avoid the nausea , I'm sure they ll chime in. Good luck , also I always snuff a single or couple seeds of a batch first to see how potent they are I recommend this for you too no matter what . And my effects for snuffing are generally faster , the peak higher and shorter and harder to absorb than oral use , which despite its less high peak is more rewarding for me solely because I can integrate the experience better , I feel the same with dmt, I generally like it better with an oral route and Maoi just so I can "keep up" with the whole thing . Plus I'm a big fan of caapii so it's win win for me. I try to use the cebil snuff as a fast teacher or healing on occasion becuase of its faster dissipation sometimes . But it's usually because I have less time to myself as I'd like , there are pros and cons to both . Hope this helped some , interesting the rectal roa, I think I've heard about that approach before , I'm positive it has benefit just never tried that