Zofran (odansetron) and Mescaline

[WizardsGarden]

Hello everyone,

I have seen a lot of discussion on the nexus regarding taking zofran with Mushrooms/Ayahuasca to negate nausea but very little discussion with respect to mescaline or cacti.

I’m curious if other members have tried it and what their experiences are?

Thanks

 

[CuriousSeeker]

2 odansetrons taken half an hour before ingestion of mescaline citrate work great to keep it down! Without it I purge too soon to get an effect.

 

[WizardsGarden]

Chat gpt had the following input regarding the safety of combining them. Anyone know if this is a legitimate concern or it it’s just AI being overly cautious.


Serotonin System:

• Ondansetron is a 5-HT3 receptor antagonist, meaning it blocks serotonin at the 5-HT3 receptors, which is why it is effective at preventing nausea and vomiting.
• Mescaline primarily affects 5-HT2A receptors (and other serotonin receptors) but does not have a direct effect on the 5-HT3 receptors that ondansetron targets.
• While the two drugs act on different serotonin receptors, combining them could create unpredictable effects, particularly if mescaline's influence on the broader serotonin system is altered.