Research 5-MeO-DMT salts for e-juice

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Probably a total outburst of cerebral flatus here, but in principle γ-hydroxybutyrate would do the job as a counter-ion too, wouldn't it?

[I'm not willing to speculate on the safety aspects of mixing GBL into a freebase vape. It's probably risky and stupid, so don't do it.]

An undergrad student seems to have looked a bit into it (without 5-MeO-DMT), her project poster makes me think she would fit right in here! (Attached)

Also, it seems that some JUUL vapes contained small amounts of GBL (undeclared) at some point: https://pmc.ncbi.nlm.nih.gov/articles/PMC8446641/
The article doesn't study whether it's harmful or not. They report one case of acute lung injury due to GBL, interestingly through oral ingestion:

A single case of ALI after chronic oral ingestion of GBL over a long period of time was reported. The patient presented in the hospital with high anion gap metabolic acidosis and acute inflammation in the lung tissue caused by chemical exposure. The physicians hypothesized the ALI was the result of GHB binding the GABAA receptor precipitating alveolar inflammation and pulmonary edema, in addition to the inhalation of small amounts of GBL over a long period of time leading to direct toxic effects to the alveoli

I agree it's probably risky.

I wouldn't recommend.. mineral salts would largely decompose before vaporizing

What mineral salts are you referring to? I don't know much about chemistry, but wouldn't 5-MeO-DMT HCl be considered an organic salt, due to the 5-MeO-DMT part?

 

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wouldn't recommend.. mineral salts would largely decompose before vaporizing

What mineral salts are you referring to? I don't know much about chemistry, but wouldn't 5-MeO-DMT HCl be considered an organic salt, due to the 5-MeO-DMT part?

The context here implies salts of a mineral acid, of which HCl is one.

The thing here is, e-juice doesn't actually involve vaporising anything but the water component of the juice, the expanding steam of which produces the driving force for the atomisation of the juice.

Are there any figures specifically relating to the thermal decomposition of 5-MeO-DMT HCl in the context of convective vaporisation? I have a vague recollection of anecdotal data suggesting that some amine-HCl salts at least partially survive the process.

To that end, I'd tentatively suggest that 5-MeO-DMT HCl would remain stable, or at least stable enough, when used in an e-juice atomiser.

An undergrad student seems to have looked a bit into it (without 5-MeO-DMT), her project poster makes me think she would fit right in here! (Attached)

Also, it seems that some JUUL vapes contained small amounts of GBL (undeclared) at some point: https://pmc.ncbi.nlm.nih.gov/articles/PMC8446641/
The article doesn't study whether it's harmful or not. They report one case of acute lung injury due to GBL

Thanks for those snippets! The data there seems to indicate that GHB in PG might be undergoing a catalytic thermal decarboxylation. Did the researchers get around to performing any further analysis beyond those two relatively simple spectroscopic techniques?

 

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The context here implies salts of a mineral acid, of which HCl is one.

Thank you for clarifying it, I didn't know about the name mineral acid, only inorganic acid. But it makes sense, now I understand.

Are there any figures specifically relating to the thermal decomposition of 5-MeO-DMT HCl in the context of convective vaporisation? I have a vague recollection of anecdotal data suggesting that some amine-HCl salts at least partially survive the process.

I haven't found anything specific to that context. This patent seems to suggest the onset of decomposition would be between 120 and 165C, if I understand it correctly: US20230382858A1 - Pharmaceutical composition comprising 5-methoxy-n,n-dimethyltryptamine - Google Patents

To that end, I'd tentatively suggest that 5-MeO-DMT HCl would remain stable, or at least stable enough, when used in an e-juice atomiser.

What would the consequences of it not being stable be? Would it then be akin to vaping freebase, or would it be some additional risk?

Thanks for those snippets! The data there seems to indicate that GHB in PG might be undergoing a catalytic thermal decarboxylation. Did the researchers get around to performing any further analysis beyond those two relatively simple spectroscopic techniques?

Not that I've seen. I found that article some time ago in the context of researching the potential dangers of leftover ethyl acetate in vape juice, in a bout of paranoia about it. The above article about GBL in vape juice is by the same researchers that wrote this one on the implications of EA in e-liquids.