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99% Pure Theobromine

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You mentioned taking the Theo around 20-40 minutes before the THH/DMT. Does Theo cause any nausea? Do you mix that with some citric acid and drink that? How does it taste? Does it give you the jitters like caffeine would?
 
yes you take it about 30minutes before the thh/dmt...and it doesnt cause ANY nausea..it makes you feel really warm and cozy..no other additives are needed..and there arent any jitters that SWIM can remember...its smoother than caffeine..
 
101mg theobromine taken orally 1.5 hour before experiment.
30mg pure DMT freebase freebased (2x)
A close friend reported the following experience:
Closed eyed visual effects were decreased, slower moving and not as colorful and vibrant as typical from this dosage. Open eyed were also attenuated (decreased). The psychological effects were certainly altered and some strange mind effects definetly lasted longer than normal. It did alter the psychological effects while at the same time decreased the visuals. Wether this is typical of all routes of admin is unknown or in combo with MAOI ?. More individuals need to conduct research with this combination. The experiment was repeated with same effects.

Subjective effects from the theobromine at this dose were apparent and consisted of stimulation without the caffeine jitters, and overall mood enhancement.
 
A good report bufoman. Is it possible that 1.5 hours might be too long before taking DMT? It seems to potentiate oral DMT, which of course is taken with an MAOI. Maybe there is some chain of order, theo potentiates the harmala alkaloid which then potentiates the DMT.

SWIM has been eating more chocolate than usual today, and drinking chocolate milk. Well, he rarely eats chocolate but had a taste for it today. SWIM will smoke some typical dose and see if it makes a difference. But he probably hasn't eaten much theo. Maybe around 5-10 oz of milk chocolate, and a glass of chocolate milk. He barely feels anything from the theo these might contain.
 
Theo has a long half life and the effects of the theo were definetly apparent before the experiment. One has to consider that it likely took 15-30 min for the plasma levels to even reach a physiological significant concentration, thus the time should not be an issue. Additionaly had it done nothing it would be safe to say a higher dose is needed or a shorter time period but there was a real and definite attenuation of the visuals. As stated the experiment was repeated as SWIM was suprised as he expected enhancement. Milk chocolate and chocolate milk as you said will likely not have a significant amount of theobromine. Also the potentiation from oral admin may result from an enhanced absorption, or as stated as activity resulted from the MAOI theo combo. There was some psychological alteration and these effects were of a longer duration however visuals were decreased significantly. More people need to attempt with pure Theo.
 
The other chemicals in chocolate are just as important, if not more important than this one.

Check out the other chemicals in Cacao.
 
I agree and these need to be looked into although I think the theo is pretty important at normal dosage levels of cocao. However it is not even confirmed if cacao potentiates freebased DMT. This will have to be looked at preliminarily. The effects of oral DMT + MAOI + Cocoa (Theo) could also use more confirmation. The MAOI factor however could alter the effects of PEA in chocolate as well as some of the endocannbinoid like compounds also the presence of choline could have an effect. Thus the MAOI in the oral combo is likely an important factor in any potentiation.
 
SWIM had intense vivid dreams as well as lucid dreams last night and another night after taking 100mg theobromine. These dreams were significantly greater than on normal nights. Theobromine may act as a dream potentiator although this is early to conclude anything this should be looked into. Interestingly both doses were taken at least 5 hours before bed.
 
I find that taking maoi+cacao before bed makes it harder to sleep. Then again, a lot of herbs has that effect on me.

bufoman said:
SWIM had intense vivid dreams as well as lucid dreams last night and another night after taking 100mg theobromine.
Perhaps it made you sleep more superficially?
 
With cacao it is hard to say as there are other active compounds also the prescense of the MAOI would likely alter the effects. SWIM gets enhanced dreams during the night when taking an MAOI during the day but hasn't tried taking directly before bed. As soon as just taking theobromine I would not be able to sleep so it is possible that the theo in the cacao is responsible for this effect in you. As you said it may make one more alert and thus recall dreams and more likely to have a lucid dream, but SWIM definitetly slept well. We really need to try with pure compounds as plants while useful have a cocktail of alkaloids present that can influence the effects. Even if the alkaloids themselves are not active they may interact through enzyme inhibition... to alter the effects of the active compound. It is the combo that is active. Also everyone is different, it could also be something I ate with the combo of theo it is hard to say. Just throwing it out there so more people can try it and see if there is any pattern here.
 
Theobromine may act as a dream potentiator although this is early to conclude anything this should be looked into. Interestingly both doses were taken at least 5 hours before bed.

This is interresting. I guess that many stimulants may increase lucid/vivid dreams, althought the difficulty might be to sleep. I experimented with nicotin patches a while ago (beeing a non smoker ;)) and it is a great LD potentiator but sleeping is not easy.

I wonder about what could be the effect of cafeine+DMT or nicotine+DMT...
 
Garulfo said:
I wonder about what could be the effect of cafeine+DMT or nicotine+DMT...
Many shamans in south america smokes mapacho, which is made from Nicotiana Rustica, which has a very high content of nicotine, about 20 times the amount found in normal smoking tobacco. In south america it is said to be the strongest plant ally, even above ayahuasca. And yes, mapacho interacts with ayahuasca in a positive way. Nicotine is also psychoactive at high doses. It is often taken as a snuff. It is also taken orally or even rectally.

During initiations they train themself to be able to withstand higher and higher amounts of nicotine, even above limits that would kill other people. They do this by ingesting larger and larger amounts of mapacho juice.

You have to be very careful when doing this, as the LD50 for humans is about 50-60 mg of nicotine. 500 mg of mapacho contains about this amount...
 
SWIM will try this Theobromine effect with sleeping

on new years..SWIM took 2 hits of acid and smoked dmt and bufotenine later on in the night..AWESOME VISUALS BY THE WAY...

anyway..in the morning SWIM made some hot chocolate(he was still awake) and added 200mg of theobromine to the mix...this created a nice warm feeling and also increased his visuals almost up to breakthrough levels...with eyes closed he was in a dmt like space..and this lasted for the rest of the day...
 
Jorkest said:
anyway..in the morning SWIM made some hot chocolate(he was still awake) and added 200mg of theobromine to the mix...this created a nice warm feeling and also increased his visuals almost up to breakthrough levels...with eyes closed he was in a dmt like space..and this lasted for the rest of the day...
Interesting observation. If you took cacao and theobromine approximately 8 hours later, we could assume that all the actives had entered the bloodstream, right? Wouldn't that mean that theobromine/cacao would potentiate the psychedelics in the brain and not by increasing absorption in this case?
 
Nicotine is active in altering dreams because acetylcholine is involved in dreaming (REM Sleep). Thus nicotine acts as a nicotinic receptor agonist and has effects on dreams, it is not a result of its stimulant activity. Also many stimulants like amphetamine decrease REM sleep and deep sleep stages. LSD in a low dose increases REM frequency and REM duration. Theobromine if it does do so should be interesting as caffeine is not known to have these effect and thus something in the pharmacology must be different to allow such effect to occur.
 
The fact that it lasted the rest of the day is interesting. Are you sure it was LSD and not DOI or DOM as these compounds have a significantly longer half life and are active longer than LSD?
I am wondering if other compounds in the chocolate are responsible or influence this enhancement as for SWIM visuals were significantly reduced, and not as colorful as usual.
Possibly try taking just the theo before freebase DMT to see what occurs.
 
I once smoked a free-base cocoa extract while i was on acid. For a few seconds there where very noticeable effects, but they didn't last longer then half a minute. I don't recommend others doing it, since it might be extremely bad for your lungs.
Theobromine doesn't make the absorbtion of DMT go quicker. It purely amplifies some signals in the brain, so the THH-DMT-theobromine combo must just have amplified the DMT immediately, while the THH supressed some of the activities that would have normally been amplified as well. So without the THH, the total of all amplified brain activity would have lead to a decrease of DMT effects.
The fact that it worked so fast has nothing to do with the theobromine but with the DMT itself.
DMT can work this fast, with no additives at all, except for the MAOI's.
DMT has an unpredictive trait. No matter how experienced you are, it can always surprise you and certainly if you try new combo's.
 
This could have been a result of a lack of oxygen or the mind state you were in (setting) especialy since it was so short acting. Additionaly many compounds would have been present in this extract. Methylxanthines can enhance the absorption of other drugs, I do not know the effect specificaly on DMT but this certainly is a possibility. I agree that DMT is absolutly unpredictable.
Theobromine would enhance the intensity and duration of any cAMP mediated effects. While THH acts as a SSRI thus enhancing the duration of DMT (by preventing MAO metabolism) while altering the effects via a number of possibilities. What gives you the impression that the amplified brain activity decrease DMT effects? I agree that Theo does decrease the visual effects of freebased DMT however the reason for this is unknown. Additionaly more people need to try this combo to replicate the study.
 
Well, there is no preference in theobromine for cAMP effects that occur within the range of the DMT mind state. The brain activity that would normally be supressed by DMT would also be amplified by how theobromine intermediates in cAMP activity. This means that part of the DMT effects would be amplified and another part of it would be reduced. At least, that's my speculation.
I think THH is something that will make the balance tip to the other side, depending on the dosage. This would have to do with the increased amounts of DMT in the blood and the increased amounts in the brain itself as well.
On this forum there where speculations on wether the visual effects of DMT would be caused by it's serotonergic effects or it's effects on other transmitters. One argument here is that there are other tryptamines such as 5-MeO-DMT that affect the serotonergic system like DMT, but that lack visual activity.
At the same time 69ron once compared 5-MeO-DMT, DMT and bufotenin and it became clear that the most visual compound hast the longest lasting effect while the least visual compound has the shortest lasting effect. It's also a fact that 5-MeO-DMT becomes more visual when it's taken in combination with MAOI's and it becomes longer lasting.
I think that how long a molecule is active within the brain itself, may have something to do with this. This is ofcourse a pure speculation, but i think that 5-MeO-DMT has a shorter lasting effect on each receptor, that once it activated a receptor, it's removed by the brains mechanisms quickly. So if you block this mechanisms within the brain, not just the stomach, it will make any compound more visual.
 
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