Excuse the long post here, but this is kind of close to my heart.
I get seriously depressed for long periods - it's been a feature of my life since I can remember. Proper crippling depression - when getting out of bed or walking is like pulling a monster truck up kilimanjaro when you're wearing ice skates.
I've never taken meds for it, because sometimes, being depressed us the only rational response to a shitty situation, and I've always believed with any illness or malady of the soul that you have to address the cause rather than the symptom. The cause for me was a lack of control over my own life, and an absence of meaning and purpose.
Before I went Inside the first time, I'd been in an eight month spiral downwards, and I could see absolutely no way out; there was a lot of bad shit going on in my life, and I was on the verge of throwing in the towel. And the Spice has changed everything. I haven't been depressed since. Things that brought me down don't bother me; I've found what I've been searching for. Things I've been studying and researching for 20 years or more suddenly make sense, have a new context and relevance that has lifted me out of the swamp.
But that's me. I made that decision by myself, though when Lord Swimming Haw Haw went in the first time, it was with his oldest and closest friend who was exploring this world already. They talked about it for ages before going In. It was like a parched desert waiting for rain - before Swim Morrison took that first suck on the bong, he absolutely knew it was what he wanted to do; he craved it, and had no problem surrendering and letting go.
Elvis Swimming Presley and his dear friend took truck loads of LSD, MDMA, shrooms and whatever else was going 15 - 20 years ago, and so was familiar with the psychedelic landscape. He'd read all the books, Huxley, Hunter S, Electric Kool Aid, Neuropharmacology For Idiots, Casteneda ... studied Buddhism, Hinduism, the Bible, read the Gnostic texts, Zen koans, Tao ... studied Zero Point energy, collective intelligence, you name it. He was SO fucking ready for hyperspace. It was like being home on trip #2. Straight up.
It's not a magic cure for everyone - lots of people have had some hairy moments Inside. There's an old saying - what you need is not always what you want - and in hyperspace, that can manifest in a very disturbing way. I'm no doctor or head shrinker; I don't think anyone should go In unless they're ready to give up everything.