I can provide diagrams if it would help 


You are trying to recite some ancient magic here, it seems. O Great Wizard, can you say it in simple terms for a normal farmer to understand?This certainly bears some relation to the pre-cyclisation step in harmaline formation, but also raises the question - why do(es) harm(al)ine have the methoxy group at the 7-position, whereas melatonin itself would give rise to the lesser know 6-methoxy-β-carboline derivatives? While melatonin is a 5-methoxytryptamine derivative, is there a corresponding 6-methoxytryptamine precursor for harmaloids, or (and?) is there an enzymatic isomerisation process either post- or pre-cyclisation which leads to the formation of the harmala alkaloids or their putative tryptamine precursors, respectively?
Answering this will require reviewing the existing knowledge on harmala alkaloid biosynthesis; apologies for veering way off on a biochemistry tangent!


I somehow deciphered your message and see it as a confirmation of mine. Basically, we do not know how the enzymes work in rue and need more research into harmala alkaloid biosynthesis.First, a small glossary:
- anything else?
- Cyclisation = joining up into a ring
- Isomerisation = changing position of some parts
- Precursor = input material
EDIT: ah, yes!
- Putative = we're not really sure but here's a reasonable idea

I don't work with harmalas/rue so much lately, but for several years I took some form of harmalas or other almost daily. I'm not sure how much my copious melatonin consumption and weird diet played a role in this (funnily enough, inspired by the book you mentioned @Iff) but eventually I noticed a more subtle vision delay effect late at night even when not taking harmalas (I referred to it as a stutter-vision) and a massive reverse tolerance to harmalas.The immersive scenarios that one can get into remind me a lot of very vivid dreams. In "DMT: The spirit molecule", Strassman mentions as a side remark that harmala alkaloids seem to be produced in the body more at night. He quickly relates it to DMT, but it wouldn't surprise me if endogenous harmalas were to play some role in dreaming.


Dried seeds is the reason I soak my sublingually/buccally overnight, then they're easily soft enough to chew and quid a bit more straight off the bat on waking up in the (hopefully) morning. A generous pinch gives a noticeable lift as well as making its own special contribution to my morning meditations, particularly in exploring the hypnogogic/hypnopompic boundary and various modes of more or less waking consciousness in entering and sustaining that state. There are some interesting levels to be accessed, undoubtedly.You guys are wild eating the seeds! Fresh seeds sound interesting but I can't imagine chewing these dried seeds, they're hard as a rock. Do you really notice a significant difference in effects in chewing vs grinding them up or making tea?
Oh, and while I hardly ever smoke weed these days, I did fairly recently share a pure weed joint with a generous helping of ground harmala seeds added to it. The effects of both were highly complementary.really adore the cannabis/harmala combination. Smoothens the weed anxiety and the psychedelic aspects of both really blossom and synergize for me. I always found it fascinating how I would be in a trance and suddenly realize I could visually see my thoughts, then they'd fade like an after-image. Tho that happens with harmalas alone of course too
One more thing for @Iff and anyone else looking into diving into rue.
Like I said, being on an empty stomach is important. And there actually really is a rue diet apart from maoi contraindications, in my decade and a half long extensive experience. Processed or fried foods are just unideal. Red meat hinders the depth of the experience. Dairy, especially butter or ghee, and garlic and onions are the things that can completely block the experience. Abstaining from these foods from at least the day before would be constructive for a decent rue immersion and healing. There are other things too, but these are the basics.
Dried seeds is the reason I soak my sublingually/buccally overnight, then they're easily soft enough to chew and quid a bit more straight off the bat on waking up in the (hopefully) morning.
I really wonder about how much of this (common, frequently reported) effect is due to unconscious expectations. I have never had a single jungle-themed experience with any plant or substance, including caapi. I've sometimes seen colorful snakes, but I see those with 2C-B as well.in the sense that the visions, messages and metaphors are all closely related to the amazonian jungle cosmovision
I believe it is mostly. Or at least i can report zero anything amazon or jungle. telepathic aliens sureI really wonder about how much of this (common, frequently reported) effect is due to unconscious expectations.
I really wonder about how much of this (common, frequently reported) effect is due to unconscious expectations. I have never had a single jungle-themed experience with any plant or substance, including caapi. I've sometimes seen colorful snakes, but I see those with 2C-B as well.
The latest visions I've had with caapi that corresponded to somewhere else were Sumerian cities and buildings, and the desert.
I'm just wondering out loud, it's not like there's a way to find an answer (maybe with double blind experiments with inexperienced people, but that's nothing we can do).
Holy cow! My first ayahuasca experience featured telepathic aliens really heavily! What were the key features for you when encountering this?I love this thread!
I believe it is mostly. Or at least i can report zero anything amazon or jungle. telepathic aliens sure![]()
I was reflecting today on how each of the batches of rue I've tried all have their own character. Now it makes me wonder whether they're amenable to being blended, or if this would amount to sacrilege@blig-blug, ime plants have their own unique characteristic visionary worlds independent from people. As an example, the rue strain that I worked intensely with for many years always gave visions of pyramids, birds of prey, and water fowl. There is no widespread shamanistic culture involving rue here, and animal spirits and pyramids are not part of the culture. Pyramids are not my field of interest. The latest strain I tested which I have just one strong experience with very clearly gave me visions of vast steppe landscapes with wild rues growing all over the place. The previous new rue strain which I have a few experiences with just gave hexagonal lattices and visions of people. İt seems to me that plants give characteristic visions (which is an extension of their characteristic spirits) much more so when they are relatively fresh. Traditional Ayahuasca is made from fresh material and the brew is not stored long term.
The esoteric spiritual tradition of this land has a strong theme of purification and aligning with capital T Truth, and the rue spirit in general is quite a force in these regards. İt was not an expectation for me, but I consistently feel this vibe from rue.

@YuxibuSounds, yes I have, a few times in full isolation. Please let us know how your diet goes if you do it. Make sure to find rue that really calls you.
@blig-blug, ime plants have their own unique characteristic visionary worlds independent from people. As an example, the rue strain that I worked intensely with for many years always gave visions of pyramids, birds of prey, and water fowl. There is no widespread shamanistic culture involving rue here, and animal spirits and pyramids are not part of the culture. Pyramids are not my field of interest. The latest strain I tested which I have just one strong experience with very clearly gave me visions of vast steppe landscapes with wild rues growing all over the place. The previous new rue strain which I have a few experiences with just gave hexagonal lattices and visions of people. İt seems to me that plants give characteristic visions (which is an extension of their characteristic spirits) much more so when they are relatively fresh. Traditional Ayahuasca is made from fresh material and the brew is not stored long term.
The esoteric spiritual tradition of this land has a strong theme of purification and aligning with capital T Truth, and the rue spirit in general is quite a force in these regards. İt was not an expectation for me, but I consistently feel this vibe from rue.