Is there any way to make mescaline more bioavailable?

[Transform]

The ideal strategy is to use an ALDH inhibitor. There are many food-based options available.


Mescaline is deaminted to it's aldehyde mostly by SSAO (with minor MAO-B involvement).

This aldehyde is oxidised mainly by Aldehyde dehydrogenase (ALDH).


If ALDH is inhibited, mescalines aldehyde metabolite can react with endogenous amines to form active substances.
There are many naturally occuring amines in the body, from ammonia to dimethylamine and phenethylamine.
It is likely that secondary amines are relevant here, including piperidine, dimethylamine and pyrrolidine. Levels of these amines can be influenced by diet. The amino acids lysine and arginine are converted by gut bacteria into piperidine and pyrrolidine respectively. Choline serves as the precrusor for dimethylamine.

With an effective level of ALDH inhibition, a dose of mescaline is much more effective.
Increasing levels of the endogenous amines mentioned above will influence the metabolites produced, and the nature of the experience.

Reports indicate that pomegranate extract/juice works well as an ALDH. There is a mention of pomegranate on this forum in the context drug potentiation. The poster was focusing on carbonic anhydrase inhibiton and seemed unaware that ALDH inhibition might have played a key role in his results.

I've made a mescaline-optimising salad using pomegranate, pistachioes, peas and parsley (there may have been some other ingredients - @downwardsfromzero has posted the recipe somewhere, I think). It was very tasty, and may even have worked to some extent.

Won't ALDH inhibition mean that pomegranate worsens hangovers - but maybe improves LSA/LSH experiences as well?

 

[Chaska]

“An alkaline diet can significantly impact Adderall excretion because urine pH plays a key role in how the drug is eliminated. Here’s a detailed explanation:

interesting, ive done extensive ph urine testing and what ive found is:

omnivore with meat : ph 3-5

vegan : ph 5-6

fruitarian: ph 6-7

intermittant fasting: ph 7s

intermittant fasting on cactus : 8s




urine after dosing usually has an opaque quality to it thats atypical, at some point ill do an extraction on the urine collections after a standardized dose
SWIM (literally) will have to explore non vegan / fruit variants as ill not be returning to animal products

 

[brokedownpalace10]

In the Mescaline subreddit, Pomegranate juice is mentioned as a potentiator. 'Course, in one thread someone claimed to have tried it and found it did not work. But the same poster said that Passionflower was a great potentiator for Mescaline. YMMV.

 

[new_science]

When I took self-extracted mescaline fumarate last December, I got much more than I bargained for. I had combined 800mg with 80mg of harmala hcl, but what I really think made the difference was that I had been on terbinafine for a few months, which inhibits CYP-2D6. I had taken my dose that day at the same time as the mescaline and the harmalas.

It's difficult for me to communicate how strong, visually, the mescaline experience was. I have taken LSD in milligram amounts, gone up to 50mg of 2C-B, and vaporized my fair share of DMT. This was easily comparable. I could not wear my eyeglasses during the peak of the experience because there was too much motion going on with my eyes open. That had never happened to me before.

While I cannot and would not repeat the experiment with terbinafine, I am definitely intrigued and will be looking for other ways to modulate this enzyme when taking cactus or mescaline in the future.

 

[Transform]

intermittant fasting: ph 7s

intermittant fasting on cactus : 8s

Hi, nice to have you back again - just to clarify, what did you intend to convey with the "7s"? "pH ~7", perhaps?