Pretreatment with 1-Methyl-1,2,5,6-tetrahydropyridine-N,N-diethyl-carboxamide (THPC) potentiated the effects of mescaline but inhibited the effects of LSD. [See comments on mescaline conjugates under mechanism of activity.]
Smythies et al. 1970
Pre-treatment or co-administration of Piracetam (Nootropil) [800 and 1200 mg levels were separately evaluated] produced marked potentiation of mescaline’s effects. Both times the combination was evaluated with the mescaline taken as acidified expressed juice from fresh San Pedro, intending to approximate a 600 mg. dose in a 70 kg. human. The effect was not homogenous. It increased the intensity, and the auditory and bright light components, of roaring wind sounds and rushing. There was a marked accentuation to the visual distortions and disturbances characteristic of peyote. There was no significant increase in colored phenomena. Subjectively it appeared to roughly double the intensity.
Case 1993 & 1994 Unpublished bioassays.
The oral administration of a subthreshold dose of mescaline sulfate (250 mg of crystalline material) 40 minutes after preadministration of 1200 mg of Piracetam seems to support this report. While, as had been reported earlier, the increase was not homogenous [Note 32], the synergy clearly pushed the effects past threshold. Also as reported earlier, it approximately doubled the effects. Justin Case 1999 (Unpublished bioassay; personal communication)
Caffeine helps maximize both rushing sensations and perceptual disturbances from mescaline and even more radically those of psilocybin mushrooms (and also 4-Hydroxy-DIPT). (Caffeine ingested, after full onset, as a strong freshly brewed cup of coffee.) We have noted similar effects from ginseng ingested (after onset) as a slow brewed tea (in a ginseng pot) made from Shiu Chu roots with Chinese licorice, aged citrus peel (Chen pi), Ligusticum (L. lucidum or L. wallichii) and Chinese cinnamon (Kuei Pi). (Ingestion of Licorice roots is specifically contraindicated with use of MAO inhibitors.) Chewed American or Chinese roots also had a similar synergistic effect, as has an herbal mixture called ‘Second Wind’ which is a powder consisting of powdered ginseng roots, guarana and bee pollen. Oral elixirs of Astragalus, Pantocrin and Panax Ginseng also seem nice additions if one enjoys maximization. We cannot vouch for the safety of any of these combinations. The fact we are still healthy and living does not constitute proof.]
