"thumb" printers report a long (a week or so) period of readjusting to the world. Or so I read.
Grof said:It became obvious after this and similar observations that high psychological resistance to LSD cannot be broken merely by an increase in dosage and that it has to be gradually alleviated by a series of sessions. It seems that there exists a saturation point for LSD somewhere between 400 and 500 micrograms; if the subject does not respond adequately to this dosage, additional LSD will not change anything in the situation.