Microdosing 5-MeO-DMT for anxiety/depression – anyone tried it?

[Space88]

Hey everyone, I’ve been dealing with long-term generalized anxiety and depression, and I’m considering trying microdoses of 5-MeO-DMT to see if it might help. I know this isn’t the most common route for 5-MeO, so I’m curious if anyone here has experimented with it in this way?

If you’ve tried it, how did it affect your anxiety and overall mental well-being? Also curious about what kind of dose did you find helpful? How often did you take it? What was your preferred method of administration?

For context, I’ve experimented with microdosing mushrooms and San Pedro in the past. Mushrooms helped a bit with social anxiety, but they also made me feel overly emotional, and ended up worsening my anxiety and depression. San Pedro had a similar effect, but more intense anxiety overall.

I’m looking for something that’s grounding and stabilizing rather than emotionally overwhelming, so I’m wondering if 5-MeO might be a better fit.

Thanks in advance for any insight you can share!

 

[Here&Now2]

I have a little experience with microdosing 5-MeO-DMT, but I unfortunately may be the wrong person to ask because I dislike microdosing in general.

At least for me, I don't think microdosing 5-MeO-DMT would help with anxiety and/or depression. That's not to say the use of 5-MeO-DMT itself couldn't help with those over time, but I didn't find that it had that effect acutely during the time the drug was active. If anything, I had increased anxiety when the microdose was active. I was using it via subcutaneous injection at doses between 100-500mcg.

I prefer singular moderate-to-large doses spread out by at least a week or two. Combined with a daily meditation practice, I've found that this can have a strong purifying effect that eventually burns away the conditions that originally led to the anxiety and depression. It physically feels like the trauma itself is removed. The periods of chemical-free sobriety between trips helped a lot in that they built a platform of stability, and I didn't get the impression that microdosing 5-MeO-DMT takes you deep enough to gain a similar purifying effect.

 

[Ernestine]

When you look at the best available evidence, the likelihood is that there is no significant effect of microdosing. Lower quality studies found some effect which disappears with better controls against bias.