There is no difference between a chemical produced synthetically (assuming stereochemistry is being considered here) and a chemical isolated from a plant.
But ron you are right that impurities may vary and LSD made by some guy in his basement probably isn't the safest bet. But pure LSD is fine there is nothing wrong with it at the doses in which is it normally consumed. But this impurity profile depends on who made it where it came from and what process was used.
There are many cases where synthetic procedures leads to purer products then isolation procedures. MANY.
I am looking at this issue not from a kitchen basement chemist point of view but from an industry point of view. Many people in society think that natural is safer automatically. They are wrong. There is NO quality control on the VAST majority of herbal and dietary products. This has lead to deaths from adulterants or improper doses or unsafe combinations.
Burnt and 69ron you guys are both putting up wonderful arguments and I'm glad to see both of you posting.
This thread was not intended to stir up drama, please don't get angry with one another.
I enjoy hearing both sides.... and keep in mind... nobody is ever going to "win" this debate...
No bad blood coming from me even if sometimes I make rough statements it just an internet debate

Ron and coatl overall I respect you both you both make strong contributions to the site and the field in general. But thats one reason I like to debate both of you.
I guess my entire view point comes from working with chemicals from nature and knowing how toxic many are. Also in my field its common that people find a poison from nature and then change it synthetically to make a safer better drug. So an unnatural process can change a natural compound into a safet better more effective compound. If this is not what happened in the industrial and acedemic world I would not be argueing this point.
My second real concern is the lack of public knowledge on these subject. This is causing serious problems withing the healthcare industry but thats a long subject that I don't want to get into know.
These chemical pharmaceutical companies produce a lot of toxic waste on a daily basis. So even if the LSD was made perfectly, it would be at the cost of our environment, so in that case again natural LSD would be better.
Well again look at the example of taxol. Man has figured unnatural ways to make a natural drug produced safer at less cost to the environment. That only one example. Also the pharmaceutical industry has some of the strictest quality and cleaniness requirements of any industry. The modern dietary supplement industry has none.
I would also argue that LSH is not better then LSD because it comes in a seed with toxic impurities. LSD when made correctly is fine and potent so you only need to make a little.
One last point concerning food. Most fruits were barely edible by our modern standards. They had to be manipulated to become palatable by man. Also apple seeds contain toxins
