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Re-crystallized Salvinorin A

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gibran2

gibran2

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I did a little experiment with a small quantity of the salvinorin A I recently extracted: I dissloved a small amount of salvinorin A in acetone, then gradually added hot water until the solution just started to get a bit cloudy.

I allowed it to cool overnight, and the next morning I was greeted by lots of small needle-like crystals. Nice!
 

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Salvinorin A is very soluble in acetone, but insoluble in water. Adding enough hot water that the salvinorin A isn't so comfortable in solution and allowing it to slowly cool lets the molecules coming out of solution to aggregate into larger crystals.

I wonder if insufflating 10 mg or so would accomplish anything, or if the purity/ordered structure of the crystals would prevent the salvinorin A from entering the bloodstream through the nasal mucosa quickly enough. I've read one interesting account of snuffing an extract of S. divinorum, but they used an unpurified acetone extract of the leaves evaporated to an amorphous powder.
 
Entropymancer said:
I wonder if insufflating 10 mg or so would accomplish anything, or if the purity/ordered structure of the crystals would prevent the salvinorin A from entering the bloodstream through the nasal mucosa quickly enough. I've read one interesting account of snuffing an extract of S. divinorum, but they used an unpurified acetone extract of the leaves evaporated to an amorphous powder.
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I tried insufflating 10mg and got no effects. :(
 
gibran2 said:
Entropymancer said:
I wonder if insufflating 10 mg or so would accomplish anything, or if the purity/ordered structure of the crystals would prevent the salvinorin A from entering the bloodstream through the nasal mucosa quickly enough. I've read one interesting account of snuffing an extract of S. divinorum, but they used an unpurified acetone extract of the leaves evaporated to an amorphous powder.
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I tried insufflating 10mg and got no effects. :(
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sugar crystals. Would be my first guess. That's a bummer, but had that been Salvinorin A and you took that dose....yikes!

--edit. What does it taste like?
 
joedirt said:
sugar crystals. Would be my first guess. That's a bummer, but had that been Salvinorin A and you took that dose....yikes!

--edit. What does it taste like?
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It's smell is reminiscent of... something that I can't place. Not unpleasant. It's also very mild - no irritation, no burning.

I was certain that an insufflated or sublingual dose is much larger than a smoked dose, so I knew I wouldn't be going too deep, but I was hoping for something. Oh well. Salvinorin A is not very eager to enter into the bloodstream.

Next test - 10mg dissolved in a very small amount of acetone, then dilute with water and take sublingually (acetone is non-toxic orally in small quantities).
 
gibran2 said:
joedirt said:
sugar crystals. Would be my first guess. That's a bummer, but had that been Salvinorin A and you took that dose....yikes!

--edit. What does it taste like?
Click to expand...
It's smell is reminiscent of... something that I can't place. Not unpleasant. It's also very mild - no irritation, no burning.

I was certain that an insufflated or sublingual dose is much larger than a smoked dose, so I knew I wouldn't be going too deep, but I was hoping for something. Oh well. Salvinorin A is not very eager to enter into the bloodstream.

Next test - 10mg dissolved in a very small amount of acetone, then dilute with water and take sublingually (acetone is non-toxic orally in small quantities).
Click to expand...


10mg is larger than the initial dose I tried with spice. I literall started witha speck, then 2 mgs, then 5 mgs, them 10, then 15, then 20...launch! :)

You are right it is going to be a larger dose, but the experience is also going to be a good bit longer than smoking salvia. I would hate to take a very large dose and be stuck in salvia space for an hour....of course I'm not really called to salvia space much. this is a pretty unexplored realm for me.
 
joedirt said:
10mg is larger than the initial dose I tried with spice. I literall started witha speck, then 2 mgs, then 5 mgs, them 10, then 15, then 20...launch! :)

You are right it is going to be a larger dose, but the experience is also going to be a good bit longer than smoking salvia. I would hate to take a very large dose and be stuck in salvia space for an hour....of course I'm not really called to salvia space much. this is a pretty unexplored realm for me.
Click to expand...
Tried it yesterday: 10mg dissolved in a very small amount of acetone, then added water to dilute. The salvinorin A immediately precipitated out, forming a milky white solution (a suspension of very fine particles of salvinorin A).

I put this in my mouth, let it circulate around - under tongue, sides of mouth, everywhere. After about 15 minutes, I swallowed it.

The result... Nothing!

Next test: 1mg vaporized in the GVG.
 
gibran2 said:
joedirt said:
10mg is larger than the initial dose I tried with spice. I literall started witha speck, then 2 mgs, then 5 mgs, them 10, then 15, then 20...launch! :)

You are right it is going to be a larger dose, but the experience is also going to be a good bit longer than smoking salvia. I would hate to take a very large dose and be stuck in salvia space for an hour....of course I'm not really called to salvia space much. this is a pretty unexplored realm for me.
Click to expand...
Tried it yesterday: 10mg dissolved in a very small amount of acetone, then added water to dilute. The salvinorin A immediately precipitated out, forming a milky white solution (a suspension of very fine particles of salvinorin A).

I put this in my mouth, let it circulate around - under tongue, sides of mouth, everywhere. After about 15 minutes, I swallowed it.

The result... Nothing!

Next test: 1mg vaporized in the GVG.
Click to expand...


Good luck :)

Careful not to vaporize too much of those crystals, I find dosing salvia extracts is hard enough... Pure salvinorin would be the last molecule i'd want to take too much of.
*- also you may want to take note of the much more powerful, ego ripping, dissociating effects of vaporizing the purified crystals... (I am relating this regarding the aggressive onset of effects of vaporized freebase DMT, compared to smoking changa or enhanced leaf..)*

The key here is to find a method for salvinorin to easily permeate the membrane... DMSO perhaps? I enjoyed the slower absorption of the quid method much more then inhaled.

maybe you should just try a much larger dose sublingually.. maybe 50-100mg? Now that may be too much, maybe try continuous dosing of 10mg until you can perceive effects? I know extremely large amounts of leaves must be chewed for a decent experience.
And maybe instead of acetone diluted in water, you could a minimal amount of ethanol, absorption is better with a minimal amount of solvent, >1ml, and the compound being completely aqueous

next step... intravenous injection? :twisted:
 
Mindlusion said:
Good luck :)

Careful not to vaporize too much of those crystals, I find dosing salvia extracts is hard enough... Pure salvinorin would be the last molecule i'd want to take too much of.
*- also you may want to take note of the much more powerful, ego ripping, dissociating effects of vaporizing the purified crystals... (I am relating this regarding the aggressive onset of effects of vaporized freebase DMT, compared to smoking changa or enhanced leaf..)*

The key here is to find a method for salvinorin to easily permeate the membrane... DMSO perhaps? I enjoyed the slower absorption of the quid method much more then inhaled.

maybe you should just try a much larger dose sublingually.. maybe 50-100mg? Now that may be too much, maybe try continuous dosing of 10mg until you can perceive effects? I know extremely large amounts of leaves must be chewed for a decent experience.
And maybe instead of acetone diluted in water, you could a minimal amount of ethanol, absorption is better with a minimal amount of solvent, >1ml, and the compound being completely aqueous

next step... intravenous injection? :twisted:
Click to expand...
Yes – I thought about how DMT effects compare when using the GVG vs. less efficient devices. But I think 1mg is a reasonable amount. I’ve had 2mg doses in the form of 20X without too much trouble, so I think 1mg isn’t unreasonably high.

I’ve thought about trying larger sublingual doses, but 100mg? Even if it worked, it would be very wasteful. Based on my extraction and growing results, that’s almost as much salvinorin A as is contained in a medium-sized plant (about 35g dried leaf).

My guess is that IV administration is more similar to smoked extract than it is to quidding, so no advantages there.
 
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