Resistance to certain entheogens

[fireandice]

Hi gang,

I've been enjoying this lifestyle for seven years now. there's been ups and downs of all kinds, but what I am about to admit about myself, I am yet to hear from someone else. It turns out I'm resistant to a very high degree to mushrooms, Lucy, and as it turns out, Ibogaine.
Ive done 7g of McKennai, tried 5g of cubensis, 500ug of Lucy. With Lucy I god some laughter, and just barely a buzz. Psilocybin is somewhat better as it grounds me, but visuals are barely there. Ibogaine gave me some depth, but nothing revealing.
The only thing that works on me as described is Deemz (Changa or free base), but I am still to experience full on breakthrough. I'd appreciate anyone knowing of similar case, or having any advice on this.

Cheers

 

[The Sofa Traveler]

Hi gang,

I've been enjoying this lifestyle for seven years now. there's been ups and downs of all kinds, but what I am about to admit about myself, I am yet to hear from someone else. It turns out I'm resistant to a very high degree to mushrooms, Lucy, and as it turns out, Ibogaine.
Ive done 7g of McKennai, tried 5g of cubensis, 500ug of Lucy. With Lucy I god some laughter, and just barely a buzz. Psilocybin is somewhat better as it grounds me, but visuals are barely there. Ibogaine gave me some depth, but nothing revealing.
The only thing that works on me as described is Deemz (Changa or free base), but I am still to experience full on breakthrough. I'd appreciate anyone knowing of similar case, or having any advice on this.

Cheers

The first thing that comes to mind is: have you started any treatment involving antidepressants, benzos, or more generally, medications that have an effect on neurotransmitters?
Also, what is your frequency of psychedelics use ? Short-term tolerance with most of psychedelics is definitely a thing but there could also be a kind of tolerance related to long-term use. If tolerance term maybe doesn't perfectly fit with this scenario we could at least talk about a certain loss of magic and dulled/diminished effects of psychedelics after long-term regular use. Sometimes, in this case, having a more or less long break from psychedelics helps bringing the magic back.
Also, last but not least, what about the substances themselves, are they from same batches or have you felt this resistance with various batches ? Inappropriate storage or just them being old might also make them loose potency.
In general, did you feel this resistance since your first ever psychedelics intake ? If yes, you might be one of those (rather rare) neuro-atypic psychedelics resistants. If not, it might be related to tolerance or lifestyle changes, including medics intakes. Nevertheless, the fact you have effects on DMT makes one think you're maybe rather on a kind of long-term use tolerance with other psychedelics. Not to mention there is cross-tolerance between most of them. DMT tolerance seems to be a thing too but acts differently and in a more obscure way.

 

[fireandice]

The first thing that comes to mind is: have you started any treatment involving antidepressants, benzos, or more generally, medications that have an effect on neurotransmitters?
Also, what is your frequency of psychedelics use ? Short-term tolerance with most of psychedelics is definitely a thing but there could also be a kind of tolerance related to long-term use. If tolerance term maybe doesn't perfectly fit with this scenario we could at least talk about a certain loss of magic and dulled/diminished effects of psychedelics after long-term regular use. Sometimes, in this case, having a more or less long break from psychedelics helps bringing the magic back.
Also, last but not least, what about the substances themselves, are they from same batches or have you felt this resistance with various batches ? Inappropriate storage or just them being old might also make them loose potency.
In general, did you feel this resistance since your first ever psychedelics intake ? If yes, you might be one of those (rather rare) neuro-atypic psychedelics resistants. If not, it might be related to tolerance or lifestyle changes, including medics intakes. Nevertheless, the fact you have effects on DMT makes one think you're maybe rather on a kind of long-term use tolerance with other psychedelics. Not to mention there is cross-tolerance between most of them. DMT tolerance seems to be a thing too but acts differently and in a more obscure way.

Thank you for your reply. And no, I am not on any meds whatsoever. I have to say that I am not a frequent user, and this is something that happened from the 1st time, when I took Lucy. I wasn't even aware of the strength of the 1st tab, and had two. I barely felt anything, as I said. I believe in my source, but I've also had mushrooms that I've grown on my own. As for the Ibogaine, this was the case recently, in a clinic.
From what I understand, there is a phenomenon of calcified pineal gland, or is that just an urban story with no meaning behind it?

 

[The Sofa Traveler]

Thank you for your reply. And no, I am not on any meds whatsoever. I have to say that I am not a frequent user, and this is something that happened from the 1st time, when I took Lucy. I wasn't even aware of the strength of the 1st tab, and had two. I barely felt anything, as I said. I believe in my source, but I've also had mushrooms that I've grown on my own. As for the Ibogaine, this was the case recently, in a clinic.
From what I understand, there is a phenomenon of calcified pineal gland, or is that just an urban story with no meaning behind it?

LSD tabs potency might still be in question, whatever the person giving it to you said about their supposed strength. It's rather common that LSD tabs are underdosed compared to claimed dosage, testing showed it clearly. It's very difficult unless lab test to know the real amount of LSD on tabs. Not to mention they can anyway lose potency with inappropriate storage (heat/light). Shrooms might loose potency with inappropriate storage too, the drying process and even preparation method if drank as tea. DMT might be less prone to adulteration hence, maybe, the fact you had effects with it. Ibogaine is a very less commonly used psychedelic with weird pharmacology, I don't have experience with it so I won't comment on it specifically.
Oh and the pineal gland calcification stuff seems more related to mythology than anything else.

 

[blig-blug]

High resistance to psychedelics for whatever reason (neurological or psychological) is certainly possible. Stanislav Grof mentions needing to give up to 1000ug LSD in a few cases; he seems to have believed it to be mostly psychological, as those cases needed lower doses afterwards. Leo Zeff used LSD to establish a "baseline dose" of psychedelics in general, as he also reports some people were more resistant. He usually gave 250ug followed by 125ug boosters (250ug in cases where there seemed to be no effect whatsoever), again he reports a few people had a baseline dose of 750ug. In the case of Zeff, he seemed it to be a matter of sensitivity, not psychological.

So, while uncommon, I would say it's definitely possible to have a resistance like you report.