DisEmboDied said:
Well all I know is that it works. If one speculates or is skeptical, then simply just try it. If one has enough, then one bowl it's not much of a sacrifice.
I am also aware of the placebo effect, and I always meta-analyze myself to make sure that I have not placeboed myself, but this was no placebo for sure plus it was instant. There was no doubt in my mind that it had worked, and if I had done more it would have been stronger.
Many speculate but why not try the experiment?
I'm in no way trying to discount anybody's personal experiences, but for me the experiment has failed every time...
TIHKAL gives this dose range for psilocin:
DOSAGE : 10 - 20 mg, orally (as the indolol, the acetate or the phosphate)
-shulgin;pihkal
(Though I've ventured far over 35mgs safely)
I doubt that anything under 6mg would even be able to produce much of an effect...
Provided you were able to inhale 10mgs in a few a hits it MAY produce psychedelia...(provided you did not destroy the active compounds with heat involved with the smoking process)
Maybe some folks mange to get over 10mgs in their system by smoking and others dont...
I'm still skeptical
(but I'm not discounting any anecdotal evidence that may be to the contrary of the conclusions I have reached. )
-eg
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Maybe there are some unidentified compounds which are effective when smoked still lurking in these fungi...Though this possibility is very very very unlikely...
N,N,N-trimethyl-4-phosphoryloxytryptamine aka Aeruginascin, found exclusively in Inocybe aeruginascens, was recently discovered...
( this compound is a 5ht3 receptor agonist, so it's not an example in a pharmocological sense, but does demonstrate that compound discovery regarding these fungi is still occurring )
I've heard people claim that 5-meo-dmt exists in some psilocybes and agarics, though I've never seen anything that would support these claims...
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I'm interested, skeptikal but interested...
if there really is something going on here it could prove to be some fascinating research, but as far as practicality is concerned I would still say that psilocybin fungi are not effective if smoked...
-eg