Unfortunately i don't think i have the skills to understand it properly :/.
Schutzgruppe – Wikipedia
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tert-Butyloxycarbonyl protecting group - Wikipedia
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Smoking nb-DMT-OXALATE
- Thread starter shake
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- nb-dmt nb-dmt oxalate
Can i ask why this guide didn't work?
I used 0.04gr Nb-DMT-oxalate
0,83 ml alchol isopropanol (0,653gr)
0.012gr baking soda.
4min and 20s to 352W into the microwave.
The guide makes sense but it turns up feeling nothing as i smoked it.
fractals4life
Titanium Teammate
Just a wild guess: but did you perhaps use baking *powder* instead of baking *soda* ? Because baking powder might not be alkaline enough, it's a mix of baking soda (AKA sodium bicarbonate ) and tartaric acid.
I used 100% pure baking soda.
N-Boc derivatives require strongly acidic conditions for deprotection. Baking soda is not acidic. What you have is a recipe for making crack reapplied to the wrong situation, perhaps 
Then again, thermal deprotection implies that simple boiling in water should work, and, on that note, using IPA (B.P. 79°C) as a solvent would keep the temperature below the suggested 80°C minimum required for it to be effective.
Then again, thermal deprotection implies that simple boiling in water should work, and, on that note, using IPA (B.P. 79°C) as a solvent would keep the temperature below the suggested 80°C minimum required for it to be effective.
N-Boc derivatives require strongly acidic conditions for deprotection. Baking soda is not acidic. What you have is a recipe for making crack reapplied to the wrong situation, perhaps
Then again, thermal deprotection implies that simple boiling in water should work, and, on that note, using IPA (B.P. 79°C) as a solvent would keep the temperature below the suggested 80°C minimum required for it to be effective.
If heat can deprotect it should i put it straight in my vaporizer and heat it? Or what am i missing?
You're missing the fact that there may be other decomposition products along with the DMT, one of which is tert-butyl alcohol, and that if you vaporise the N-boc, it's a carbamate which may well have toxic effects considering a major use of carbamates is in pesticides, along with there being a rate of decomposition - it takes time for the reaction to happen, so you have to heat it in a controlled fashion for a particular length of time, and then purify the resulting product before further use.
Sorry, I'm not entirely clear what you mean by this. Yes, deprotection can be a pain in the ass!
I mean, since deprotection is a pain in the ass, it would be better to just buy the freebase form directly.
Is there any easy guide that can be done at home with easily accessible ingredients?
Wouldn’t it be immediately quenched by any nucleophile, and hydrolysis would take care of it? into the tert-butanol.
It’s probably not a good idea to go down this route if you’re on a tight budget. You’d be better off making an extract instead. That way, you can be more certain that you’ll end up with a clean product, and it’s a well-established process where we can offer proper guidance.
At the moment, there are no guides that describe exactly what you’re trying to do in a way that reliably leads to a good end result. While I don’t doubt that it’s possible, experimenting and then having the result analyzed in a lab will almost always be more expensive. That said, it is also the most interesting path, since you’d be making a real contribution.
Still, based on your other post, I get the sense that might be a bit too ambitious for you right now. So my advice would be: pause this project for now, save your material, and see if you can do an extraction and work with that instead. Once your situation improves, you can look for a method that really works, or maybe someone else will have done the groundwork by then and you can still convert then.
I can't extract anything at the moment and in the near future. I can follow an easy guide step by step to deprotect it tho, what material i need? Are they easy to find?
@shake , the deprotection is needed for both oxalate and freebase forms. Freebasing the oxalate is very simple (just look up any DMT salt to freebase Tek), the issue is that regardless of that you need to remove that N-Boc part to obtain n,n-DMT, because as @Transform explained, N-Boc-DMT is likely to produce harmful substances when vaporized.
Got it, the regarding the N-boc part is there any step by step guide easy to follow? ( No Wikipedia pls, i mean a real guide).
Thx for the patience guys
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If you can't extract, your ability to deprotect remains questionable, since you'd ideally carry out a miniature extraction after the deprotection stage, either because you'll need to convert the product back into freebase form in the case of the acidic deprotection, or as a precautionary cleanup in the case of the thermal route.
I think you're simply going to have to be patient - hyperspace ain't going away and currently the universe appears to be saying "just you wait a little while". Or, you'll see that all the information is already there for you to be able to proceed and you'll just have to assemble it into a meaningful set of procedures, which would be a great way of using your waiting time
Is this stuff orally active and safe with an MAOI? Just a thought.
I mean, it pould be great if stomach acid would do the job of deprotection. Ingesting a few mg of t-butanol might not be so terrible. From where we're standing, we have no way of knowing whether the substance is what someone once claimed it to be, nor how it would respond to test kit reagents (best to look this one up though - protestkit might have some info already, for example) so I'd be very hesitant to ingest some random powder without a very convincing analysis result.
Also, see my previous post which mentions carbamates… would you ingest an untested pesticide analogue?
If you can't extract, your ability to deprotect remains questionable, since you'd ideally carry out a miniature extraction after the deprotection stage, either because you'll need to convert the product back into freebase form in the case of the acidic deprotection, or as a precautionary cleanup in the case of the thermal route.
I think you're simply going to have to be patient - hyperspace ain't going away and currently the universe appears to be saying "just you wait a little while". Or, you'll see that all the information is already there for you to be able to proceed and you'll just have to assemble it into a meaningful set of procedures, which would be a great way of using your waiting time
the point is that i have no access to any plant so no extracting is possible.
Second point is : waiting for what? That's still a relatively old compound (1y+) and nothing has come up yet.
I am going to have a go another couple of time although i am short on time lately.
Btw i have already tried to ingest it a small amount and i felt nothing ( no health issues either)