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Sublingual Mescaline?

Migrated topic.
Mescaline is most definitely active sub lingually, wether it is more potent is the question. It probably is, but how much is required? But you said that you eventually swallowed it, thus it had not yet all absorbed so it may have still been the oral dose that was active.

Ott has shown that small amounts of MAOI's can potentiate sub lingual and nasal compounds. Maybe some of the isoquinolines in the cacti potentaited the sub lingual mescaline. They could also do so orally but as Ott showed only a small amount of MAOI's are needed to potent sub lingual or nasal compounds.
 
bufoman said:
Mescaline is most definitely active sub lingually, wether it is more potent is the question. It probably is, but how much is required? But you said that you eventually swallowed it, thus it had not yet all absorbed so it may have still been the oral dose that was active.
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Yeah, it could have just been active from the oral ingestion. SWIM never tried taking 60 mg of pure mescaline HCl orally in a capsule. Maybe he’s sensitive enough to feel it that way without any sublingual absorption at all? He would really like to test this out by doing it sublingually and then spitting it out and washing his mouth so none can absorb through the stomach, but he’s exhausted his mescaline supply, and it’s so expensive to get more to test with.
 
If you leave it there long enough it should all be absorbed. No need to spit. But yea it wouldn't be unheard of if you got some activity from this amount. SWIM seems to be sensitive to these substances, maybe low endogenous MAO phenotype.
 
This is very interesting topic. SWIM's FOAF is really interested in different ways of taking mescaline. Last week he had 800mg of mescaline fumarate, it was an exceedingly and overwhelmingly beautiful experience. But he had to extract 200g of cactus powder to get that amount. This is not really satisfactory when considering yield versus extraction trouble.

Sublingual seems a good way to go, so he might give it a try at some point.

More studies on this are absolutely imperative! There has to be something that potentiates mescaline at least 2- or even 5-fold.

This is what SWIM's FOAF proposes;

1) snorting mescaline; has anyone actually done it?

2) oral mescaline in conjunction with harmala MAOIs? He knows some people say that this is contra-indicated but he does not know whether this information is trustworthy.

3) smokeable mescaline? again, people quote that mescaline freebase is a pretty caustic oil and should not be smoked...

How valid are these claims? What are the Nexian's opinions on these issues?
 
Infundibulum said:
This is very interesting topic. SWIM's FOAF is really interested in different ways of taking mescaline. Last week he had 800mg of mescaline fumarate, it was an exceedingly and overwhelmingly beautiful experience. But he had to extract 200g of cactus powder to get that amount. This is not really satisfactory when considering yield versus extraction trouble.

Sublingual seems a good way to go, so he might give it a try at some point.

More studies on this are absolutely imperative! There has to be something that potentiates mescaline at least 2- or even 5-fold.

This is what SWIM's FOAF proposes;

1) snorting mescaline; has anyone actually done it?

2) oral mescaline in conjunction with harmala MAOIs? He knows some people say that this is contra-indicated but he does not know whether this information is trustworthy.

3) smokeable mescaline? again, people quote that mescaline freebase is a pretty caustic oil and should not be smoked...

How valid are these claims? What are the Nexian's opinions on these issues?
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I prefer to insufflate mescaline. I have found no increase in "potency" and still must have about 500mg to get a good head from it. I do like that I have no stomach issues and that it does come up about twice as fast. It burns a bit but overall is easier on tissues than cocaine and the burn fades rapidly. I have on one occasion insufflated close to 1500mg in a 24hr period (festivals are like that ,eh?) and had a sore nose for a couple days but not anything more than mild allergies. 750mg good clean eggshell mescaline snorted over about an hr. is very nice. Smaller doses are good for "chore work".
IMO insufflation is very superior to sublingual. The taste of mescaline is to me pretty nasty. A nice cold drink takes care of the taste from the drip when insufflated and the sinuses are a much larger surface area for absorption.
Just PLEASE make sure you have washed your product VERY well as any excess acid will play havoc on your sinus.
Harmala can be used with mescaline safely, although I would not go for a 1000mg dose and add harmala. I have however used 50-75mg highly pure mixed harmala alkaloids with 500mg mescaline with only positive effects. BP and heartrate normal, slight increase in blood sugar.I am highly cautios of my BP and pulse when using "stimulating" substances as I have had a heart attack a decade ago. Any new combo is tasted slowly and monitored carefully for elevation of pulse or BP. To date I have had no bad reactions to harmala with any of the primary psychedelics although it is not as potentiating with LSD as with mescaline and psilocybin.
Hope this helps
WR
 
Maybe the different compounds in cactusses have a synergistic effect. I had noticeable effects once with 4 peyote bud's. I find it hard to believe that they would hold a threshold dose of 200 mg. On the other hand; maybe sensitivity to mescaline just varies a lot from person to person.
 
Well SWIM would NOT consider trying to snort anything else again that’s for sure. He always gets sick when something foreign is in his nose, no matter what it is.

If snorting mescaline works then for sure it would work sublingually. SWIM doesn’t mind the taste of mescaline one bit, so sublingual use suits him just fine.


It’s likely that sensitivity to mescaline varies from person to person and that the published dosage levels are not accurate for everyone. SWIM tends to require much less psychedelics than other people, even though he’s a very heavy muscular wide bodied guy (weighing close to 300 pounds, but not fat). His brother weighs almost half what he weighs but usually required 4 times the dose for most psychedelics.

At some point SWIM will get lucky and find a cactus that has a good amount of mescaline and then he’ll be able to test sublingual potency versus oral potency. Until them hopefully someone else on this forum will be able to provide more information on sublingual use.
 
Infundibulum said:
This is very interesting topic. SWIM's FOAF is really interested in different ways of taking mescaline. Last week he had 800mg of mescaline fumarate, it was an exceedingly and overwhelmingly beautiful experience. But he had to extract 200g of cactus powder to get that amount. This is not really satisfactory when considering yield versus extraction trouble.
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Seems SWIY’s experiencing poor yields too from cactus. 800 mg is much more than SWIM ever extracted from 200 grams of dry cactus though. Most he ever got was 150 mg from 200 grams :(

How was mescaline fumarate? Was it very crystalline? How was it created?

Infundibulum said:
Sublingual seems a good way to go, so he might give it a try at some point.

More studies on this are absolutely imperative! There has to be something that potentiates mescaline at least 2- or even 5-fold.

This is what SWIM's FOAF proposes;

1) snorting mescaline; has anyone actually done it?
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I’ve read a few accounts of it being active that way, but not more potent. I’ve read it hits your faster, that’s about it.

Infundibulum said:
2) oral mescaline in conjunction with harmala MAOIs? He knows some people say that this is contra-indicated but he does not know whether this information is trustworthy.

3) smokeable mescaline? again, people quote that mescaline freebase is a pretty caustic oil and should not be smoked...

How valid are these claims? What are the Nexian's opinions on these issues?
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I’ve heard of people smoking mescaline HCl with success, but I can’t find much details about dosage and effects.
 
From the mycotopia forum:
Tregar said:
You will only be able to get about 25% of the dose to absorb sublingually, I've tried it, but only got mild effects...I let it absorb over and over and over over a 1/2 hour period, ended up wasting too much of the dose, the amount that wouldn't absorb sublingually. Ergopharm did some research on this for a while using sublingual cyclodextrin compounded testosterone, of a 25mg dose, about 5mg was able to be absorbed sublingually under the tongue, between the gums, swished around, etc. Since an active dose of mescaline is around 200mg, about 50mg will be absorbed...I've never tried it again since my one experiment, I got effects but it took about 1/2 hour of swishing, letting it sit under the tongue, etc...for very very mild effects.

On the other hand, if your mescaine is pure, be it white or translucent, so long as it is not sanchez brown or tan, it can be smoked in a glass bulb or special pipe like people use for dmt, you can easily get a 200mg dose in this way, it does work, it comes on in about 20 minutes and will last the standard 6 to 8 hours or more this way, depending on the dose. There is practically zero body load but your stuff must be clean in order to be smoked. It has been done by a handful of people with clean stuff...and actually taste pretty good, somewhat sweet. I'll give it a shot myself when my stuff is crystalline pure after a re-crystallization soon in about 4 weeks. This has been cofirmed by me! and psychohipe, They have smoked mescaline hcl many times in dreams, it does work. You cannot smoke mescaline sulphate, only mescaline hcl.
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Dagger said:
From the mycotopia forum:
Tregar said:
You will only be able to get about 25% of the dose to absorb sublingually, I've tried it, but only got mild effects...I let it absorb over and over and over over a 1/2 hour period, ended up wasting too much of the dose, the amount that wouldn't absorb sublingually. Ergopharm did some research on this for a while using sublingual cyclodextrin compounded testosterone, of a 25mg dose, about 5mg was able to be absorbed sublingually under the tongue, between the gums, swished around, etc. Since an active dose of mescaline is around 200mg, about 50mg will be absorbed...I've never tried it again since my one experiment, I got effects but it took about 1/2 hour of swishing, letting it sit under the tongue, etc...for very very mild effects.

On the other hand, if your mescaine is pure, be it white or translucent, so long as it is not sanchez brown or tan, it can be smoked in a glass bulb or special pipe like people use for dmt, you can easily get a 200mg dose in this way, it does work, it comes on in about 20 minutes and will last the standard 6 to 8 hours or more this way, depending on the dose. There is practically zero body load but your stuff must be clean in order to be smoked. It has been done by a handful of people with clean stuff...and actually taste pretty good, somewhat sweet. I'll give it a shot myself when my stuff is crystalline pure after a re-crystallization soon in about 4 weeks. This has been cofirmed by me! and psychohipe, They have smoked mescaline hcl many times in dreams, it does work. You cannot smoke mescaline sulphate, only mescaline hcl.
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I read that before on that other forum a few days ago. I don't know how accurate that information is. I don't know that guy’s reputation. I’m skeptical of that guy’s report. It doesn’t make sense to me that it would be very active by snorting and only weakly active sublingually.

SWIM did his last 150 mg of mescaline from a Torch extraction several hours ago (one bought on-line). He let the mescaline HCl sit under his tongue for 10 minutes before swallowing. Effects were felt within 30 minutes. It peaked after about 4 hours. SWIM is still tripping pretty hard off of that 150 mg. It really took SWIM by surprise. The peak kept building and building in waves. The Torch extract had the effects of completely pure mescaline. There wasn’t a hint of sedative effects at all. SWIM could barely sit still from all the mescaline energy. It was awesome, but gave SWIM the chills too. During the peak things were moving and shifting in his visual field. There were closed eye visuals and lots of spiritually significant effects that occurred in SWIM consciousness. No nausea at all by the way. SWIM even ate several times during the trip.

SWIM is going to get more of that same Torch and do another extraction and give in and test a sublingual only dose, just to see if what that guy above has said is true or not. It seems to SWIM that he’s getting pretty strong effects from such a weak dose of mescaline. He doesn’t recall such strong effects from 150 mg in his early days when he had access to pure synthetic mescaline back in San Francisco. Maybe the sublingual trick is making it stronger, or maybe SWIM is just more sensitive to mescaline now?
 
Nice info everybody!

Re to 69ron, mescaline fumarate was made using FASA on xylene. Briefly, the cactus powder was slightly boiled in water for 2 hours to reduce the sliminess, then all the stuff (unfiltered) was placed in a gallon container (with a gallon of water) and equal amount of lye was added to it. Too high a pH also helps a lot on breaking the sliminess. After a period of several days all the sliminess went away, and freebase mescaline was pulled with xylene, then precipitated as fumarate salt out of xylene using FASA. Salts Washed with acetone a couple of times, then dried.

Mescaline fumarate is a white powdery material, it looks and feels like chalk and it looks more than it weights (i.e. what "looks" like a gram is actually 100mg)

SWIM's FOAF is still pulling minuscule amounts from the cactus.

He'll also try to freebase and smoke it at some point, if that's too stupid please slap him before it's too late.
 
Would be nice to have more info on that, i.e. how much was smoked, how was it smoked (joint style vs dmt-style), how fast was the onset, how long did it last, but most importantly how was the experience and how does it compare with oral mescaline.

I've seem other posts around that smoking mescaline "works" but what does that mean?
 
Infundibulum said:
Would be nice to have more info on that, i.e. how much was smoked, how was it smoked (joint style vs dmt-style), how fast was the onset, how long did it last, but most importantly how was the experience and how does it compare with oral mescaline.

I've seem other posts around that smoking mescaline "works" but what does that mean?
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Tregar from mycotopia said:
On the other hand, if your mescaine is pure, be it white or translucent, so long as it is not sanchez brown or tan, it can be smoked in a glass bulb or special pipe like people use for dmt, you can easily get a 200mg dose in this way, it does work, it comes on in about 20 minutes and will last the standard 6 to 8 hours or more this way, depending on the dose. There is practically zero body load but your stuff must be clean in order to be smoked.
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It's been 8 hours and SWIM is still tripping. Watching Robot Chicken on the DVR is a blast. SWIM likes coffee mixed with mescaline. It seems to give it a boost and clear up the tongue tied effect SWIM gets from mescaline.

SWIM now has a lot of fumaric acid. Next time he’ll try making the mescaline fumarate (should be much healthier).

As far as smoking mescaline, I’d definitely like to see more details on that subject.

And as for mixing mescaline with THH, that sounds like an awesome experience to be had. I doubt it will make the mescaline more potent though. Harmine and harmaline will make mescaline 2-3 times more potent though. THH doesn’t seem to increase the potency of other compounds even though it’s an MAOI, but it does tend to add a whole knew psychedelic dimension to the experience of other psychedelic compounds. With mescaline I imagine it would probably ease the nervous anxiety a little, but at the same time make you more stimulated, and probably make your mind more focused during the experience. It’s definitely on SWIM’s to do list.



One thing that SWIM noticed this time that was quite weird was that he could smell the mescaline HCl during the peak. It was as if he was sweating mescaline HCl out of his skin or it was being excreted in his mucous or something. I don’t know if that possible.

Right now SWIM non longer smells mescaline HCl on his body but definitely smells hydrochloric acid all over. What the fuck? Does mescaline come apart in the body releasing hydrochloric acid in your body? SWIM’s mouth tastes like hydrochloric acid, everything smells like hydrochloric acid, especially his body.

Maybe it’s just that SWIM is tripping still and its just an illusion.



SWIM is going to try a little bit of kola nut and see what happens. Usually kola nut increases the psychedelic effects of most tryptamines for SWIM, but he’s never tried it with mescaline before. He’s going to make some kola extract tea in a minute and see what happens.
 
69ron said:
As far as smoking mescaline, I’d definitely like to see more details on that subject.
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duaut from mycotopia said:
The real trip was smoking the Mescaline in her glass tube, WHOA, the trip gets more intense. It's a mind warp, OMG how beautiful. SWIM can not explain the intensity of the experience, but she only puffed about 60mg of white crystals about 4hrs into the trip. SWIM read about ~me doing this and has wanted to do this for awhile. Now with clean white Mescaline anything is possible.
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From here:
Some really nice mescaline crystals there...

duaut from mycotopia said:
Lots of negative speculation here from those who don't know and have never tried smoking good pure white mesc hcl.

IT WORKS GREAT!!! Hand down. It tastes good too. it will extend your trip another 6hrs easily and the visuals are gentle and intense.
SWIM has smoked mesc quite a few times, and did during last weeks full moon.
60mg is the way to go after dosing with 200mg mesc hcl about 5hrs into the journey. Geometry and webs form with such intense color. SWIY can keep on tripping all weekend if they have enough to puff. Go slow and have fun.
Those who have never done it shouldn't say it won't work when it has been proven to work many years ago. The data is there and many have enjoyed the deeper so called spiritual experience.
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Anyway, It does not seem to be more potent this way compared to eating it.

69ron said:
And as for mixing mescaline with THH, that sounds like an awesome experience to be had.
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Be careful with it. Start low. From what I have heard, it can potentiate mescaline by quite a bit.

And what about theobromine? Could it potentiate it like it does DMT?
 
whoa!

does anyone know the vaporisation point of mescaline HCl?

And a good starting amount to smoke? 200mg? Good starting amount is defined as the amount that makes you trip balls!
 
Check this thread for extraction:
Mescaline Extraction Tek

Extraction yield:
waylitjim from mycotopia said:
What is the yield potential starting with a kilo of peruvian torch skins?
I average about 15 grams of Mescaline sulfate from a kilo of cacti skins. To make mesc crystals you have to add a acidic functional group, like using sulfuric acid (sulfate), hydrochloric (hydrochloride)
About 500mg is a good strong dose of Mescaline sulfate.
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waylitjim from mycotopia said:
Following this extraction tek, it's possible to yield 400 mg (one strong dose) per foot of fresh cactus used.
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