Ok so SWIM did one more test. This time instead of Datura stramonium, he used Datura inoxia. He used 2 seeds (together weighing 20 mg) and 74 mg of mescaline HCl.
The experience was very different. Not nearly as euphoric, just about as euphoric as mescaline normally is. There's a strange feeling in SWIM's throat from this combination. Sort of a lump in his throat, and at the onset there was very slight nausea at times. Datura inoxia has extremely different effects.
The trip was more relaxed than usual. Scopolamine is nearly the only alkaloid present in Datura inoxia seeds and it's a known sedative so this accounts for the more relaxed feeling. Visuals were increased at least 2 fold. The body feels very at ease with this. It's extremely tranquil and easy to carry on conversation with this combination. It's not nearly as nice as the combination of mescaline and Datura stramonium seeds.
Also, SWIM did notice a very slight feeling of nausea during the first hour. He never feels nausea with mescaline so he knows the Datura inoxia caused it. That's very unexpected because scopolamine is used to treat motion sickness, so why would it cause nausea in combination with mescaline? At the moment SWIM feels a sort of lump in his throat which is part of the slight nausea that faded.
The trip is more LSD-like, and the visuals are much stronger for this dose of mescaline. However, the scopolamine in the seeds sort of brought the feeling tone down a notch with it's light sedative effect.
All in all, mescaline + Datura stramonium is a KICK ASS COMBINATION, but mescaline + Datura inoxia is so and so. There are more visuals, but at the cost of slight mental cloudiness at the onset, slight nausea at the onset, and a little less euphoria for the first few hours. However both make mescaline more LSD-like, both increase and alter the visuals quite a lot. With Datura stramonium seeds, there was absolutely no nausea and the mind was clearer, and there was more euphoria. It's really is much better to use Datura stramonium for this particular psychedelic.
Does anyone have any ideas why scopolamine (Datura inoxia) would cause a little nausea when mixed with mescaline, but hyoscyamine (Datura stramonium) prevents it?