It appears Egzoset was invited by Transform to react, and since my background is in vaporism rather than DMT specifically, it seemed appropriate to ask an AI for assistance regarding these two statements:
...the manual said that the smallest drops penetrate deepest into the lungs.
Studies have shown that drops can be too fine.
The answer I received was that both contain some truth, depending on physical dynamics...
I've experimented with several AI‑driven "discussions", especially micro-droplet heat-shrinking in relation to "gasification" (D²‑law) as in the Sublimator vaporizer of Enrico Bouchard, which later inspired a variety of devices like Camouflet's Convector, the Herborizer (injector stacking) and Vestratto's Tornado:
'Gasification apparatus, gasification assembly kit and method for gasification and concentration of a gasifiable compound'
His patent makes no explicit mention of large micro-droplets being trapped early in the mouth and throat, or ultra-fine aerosol droplets getting exhaled even before deposition could occur. Although he focused on managing energy in sequential stages and preventing premature condensation (which we can now link to a sub-micron liquid phase), that said practically nothing about an optimal Mass Median Aerodynamic Diameter (MMAD), Brownian motion or the Leidenfrost effect... In short this Sublimator concept always revolved around promoting conversion into a gas and not much else besides intrinsically preventing combustion by design.
While Bouchard's contribution only concerns cannabis consumers, my perception here is that there's some fair consensus reflecting the requirements of an even more delicate molecule called DMT. So the community's interest in ultrasonic nebulization seems fully justified, and hence my own suggestion would be to seriously consider post mechanical-nebulizer thermal sublimation:
#1) Release a mechanically-calibrated (2 ~ 4 µm) mist at room temperature
#2) Apply heat to change its thermal phase until it behaves the same as a gas
That ain't no easy goal but the prospect might prove fascinating.
It's already clear 5 ~ 10 µm would lead to oropharyngeal capture, while Brownian motion dominating below 0.5 µm translates to an exhalation loss without tissue contact (a purge!)... Consequently, the optimal liquid MMAD range of an aerosol appears to be 1 ~ 3 µm, because it maximizes alveolar deposition via sedimentation.
However, the ultimate purpose of deep flash-vaporization as in post-nebulizer thermal sublimation is to reach the gas-phase regime: mechanical mist shifts to vaporous state, which removes droplet limitations. But a true molecular gas traveling through cooling airways will face immediate condensation, so this calls for strict thermodynamic control enabling proper management of micro-droplet thermal breakdown prior to subsequent cooling, actively preventing chaotic condensation. Such novel system would imply a temporary phase transition to achieve its controlled condensation - shaping expansion into a perfectly uniform aerosol aiming for your sweet-spot range - ready to swiftly dissolve into alveolar surfactant then diffuse into your blood stream to induce an immediate "breakthrough".
IMO your people will have to engineer some open-loop "ballistic" energy pulse to master that sort of goal. Volts, Ohms, and Watts talk won't suffice; one must also deal with Joules vs. mg, etc.
Good day, have fun!!
Ref.:
Ultrasonic nebulization platforms for pulmonary drug delivery (2010-Jun-7)
Assessing the temperature of thermally generated inhalation aerosols (2010-Oct-20)
Devices for Improved Delivery of Nebulized Pharmaceutical Aerosols to the Lungs (2019-Oct-1)
Aerosol droplet-size distribution and airborne nicotine portioning in particle and gas phases emitted by electronic cigarettes (2020-Dec-10)
