PsilocybeChild
Rising Star
Hello,
Yohimbine can cause hyper-sensitive responses with adverse effects in some people.
I am not one of those. I enjoy Yohimbine very much as a stimulant which I find good for physical endurance and which feels somewhat nice and when used with other substances, as it effects serotonin receptors. I feel that agonizing certain 5-HT, d2 and the NMDA receptor has benefits as a whole.
Now I've been taking yohimbine almost daily for months, and I don't recommend experimenting with higher doses of it unless you have daily use experience, a tolerance, and have titrated up to 15-20mg of it orally.
The product I have came with a spoon with a tiny 5 mg scoop on the end. I have started out taking 1 dose, then 2, then 3, now sometimes 4 orally with no major extra effects.
The other night I insufflated about 20mg of the powder. The physical effects from this are not too nice and reminded me physically of 5-meo-dmt. A hypertensive / cardiovascular restrictive effect. I smoked a little cannabis to try and lower blood pressure than I layed down in the dark. The cannabis didn't seem to help but after lying down a while the constrictive effects relaxed away completely and I began to have psychedelic effects including non-saturated but detailed visions.
I should mention that I had a glass of absinthe earlier and good absinthe will make other drugs more trippy.
I imagined that yohombine is quite similar in effects when insufflated as traditional snuffs. Unpleasant body sensations but when you lie down and relax, a novel mind-expanding experience.
I felt that Yohombine and 5-MeO-DMT felt quite similar and when I looked up the receptors, saw that they both have high to moderate affinity for 5-HT1A and a weaker affinity to 5-HT2A (5-MeO-DMT's active metabolite Bufotenin mainly acts on the 5-HT2A receptor).
P.S. -- In the past I used to pour a full-spectrum alcohol extract tincture dose over a bowls worth of cannabis and let dry before smoking it. I felt that it added subtle but enhanced effect to the cannabis high.
en.wikipedia.org
Caution: Please leave yohimbine alone as a recreational psychedelic unless you have experience, patience, tolerance and respect with it.
Yohimbine is a central nervous system stimulant and can cause adverse effects in higher doses when used without respect and caution.
Yohimbine can cause hyper-sensitive responses with adverse effects in some people.
I am not one of those. I enjoy Yohimbine very much as a stimulant which I find good for physical endurance and which feels somewhat nice and when used with other substances, as it effects serotonin receptors. I feel that agonizing certain 5-HT, d2 and the NMDA receptor has benefits as a whole.
Now I've been taking yohimbine almost daily for months, and I don't recommend experimenting with higher doses of it unless you have daily use experience, a tolerance, and have titrated up to 15-20mg of it orally.
The product I have came with a spoon with a tiny 5 mg scoop on the end. I have started out taking 1 dose, then 2, then 3, now sometimes 4 orally with no major extra effects.
The other night I insufflated about 20mg of the powder. The physical effects from this are not too nice and reminded me physically of 5-meo-dmt. A hypertensive / cardiovascular restrictive effect. I smoked a little cannabis to try and lower blood pressure than I layed down in the dark. The cannabis didn't seem to help but after lying down a while the constrictive effects relaxed away completely and I began to have psychedelic effects including non-saturated but detailed visions.
I should mention that I had a glass of absinthe earlier and good absinthe will make other drugs more trippy.
I imagined that yohombine is quite similar in effects when insufflated as traditional snuffs. Unpleasant body sensations but when you lie down and relax, a novel mind-expanding experience.
I felt that Yohombine and 5-MeO-DMT felt quite similar and when I looked up the receptors, saw that they both have high to moderate affinity for 5-HT1A and a weaker affinity to 5-HT2A (5-MeO-DMT's active metabolite Bufotenin mainly acts on the 5-HT2A receptor).
P.S. -- In the past I used to pour a full-spectrum alcohol extract tincture dose over a bowls worth of cannabis and let dry before smoking it. I felt that it added subtle but enhanced effect to the cannabis high.
Pharmacology
Yohimbine has high affinity for the α2-adrenergic receptor, moderate affinity for the α1 receptor, 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1F, 5-HT2B, and D2 receptors, and weak affinity for the 5-HT1E, 5-HT2A, 5-HT5A, 5-HT7, and D3 receptors.[13][14] It behaves as an antagonist at α1-adrenergic, α2-adrenergic, 5-HT1B, 5-HT1D, 5-HT2A, 5-HT2B, and D2, and as a partial agonist at 5-HT1A.[13][15][16][17] Yohimbine interacts with serotonin and dopamine receptors in high concentrations.

Yohimbine - Wikipedia
Caution: Please leave yohimbine alone as a recreational psychedelic unless you have experience, patience, tolerance and respect with it.
Yohimbine is a central nervous system stimulant and can cause adverse effects in higher doses when used without respect and caution.