Zero proof DMT is made in your head.

[Infundibulum]

It is definitely produced in our bodies:

Biosynthesis of N,N-dimethyltryptamine (DMT) in a melanoma cell line and its metabolization by peroxidases - PubMed

Tryptophan (TRP) is essential for many physiological processes, and its metabolism changes in some diseases such as infection and cancer. The most studied aspects of TRP metabolism are the kynurenine and serotonin pathways. A minor metabolic route, tryptamine and N,N-dimethyltryptamine (DMT)...

www.ncbi.nlm.nih.gov

In this case I believe they mean specifically the pineal gland. Though it has been found in the pineals of live rats, I doubt anyone will be volunteering to have their head sliced open to settle and age-long Nexus debate.

Considering the topic was released years ago, that journal released this year, it is relevant to the subject itself. Pineal or not, our SK-Mel-147 cells are producing this molecule, and it plays a role in the nature around us. It's a neurotransmitter, closely related to Serotonin and Melatonin, both amazing tryptamines. This adds to the discussion, as those who come into this thread may be looking for where it's produced, and now they will find it.

Very interesting paper, and a fresh one too! It gives an alternative twist on how DMT may also be metabolised in the body.

Also, DMT is not a neurotransmitter, or at least it has never be shown to be packed in presynaptic vesicles and released in the synapses (=the definition of neurotransmitter).

 

[goddard]

now it has been found !!!

'Mystical' psychedelic compound found in normal brains

In the past few years, thrill-seekers from Hollywood, Silicon Valley and beyond have been travelling to South America to take part in so-called Ayahuasca retreats. Their goal: to partake in a brewed concoction made from a vine plant Banisteriopsis caapi, traditionally used by indigenous people...

medicalxpress.com

 

[Ulim]

now it has been found !!!

'Mystical' psychedelic compound found in normal brains

In rat brains :?

 

[benzyme]

now it has been found !!!

'Mystical' psychedelic compound found in normal brains

In rat brains :?

yup. :lol:

 

[dragonrider]

now it has been found !!!

'Mystical' psychedelic compound found in normal brains

In rat brains :?

yup. :lol:

Are you people thinking what i'm thinking? The mystery of DMT-entities finally solved...they are rats who can telepatically communicate with other creatures that also have DMT in their brain!!!

 

[benzyme]

like rabbits? maybe.

I've been looking at this old paper on the biological transformation of endogenous compounds such as melatonin, into potential MAOIS.

"The pictet-spengler reaction and biogenic tryptamines: Formation of tetrahydro-β-carbolines at physiological pH"
James C. Callaway, Jukka Gyntber, Antti Poso, Mauno M. Airaksinen, Jouko Vepsäläinen, 1994.

I've been speculating for many years, that pinoline (6-MeO-THBC), a known melatonin (which is secreted in the absence of light) metabolite, not dmt, may be responsible for some of the immersive and visual aspects of deep meditation and sensory deprivation.