Experience with @sabnock1990 discovery about tryptophan+b6 and b12+rue

[modern]

I'll give this an attempt some day. I have high CYP2D6 based on how my body responds to opioids and duration of activity. I've taking about a few months off of taking caapi tea daily in the morning myself. This is an interesting experience but how low a harmala dose will it work with?
200mg harmala is usually enough to activate dmt for me. 8g seeds is like 300-400mg so not too much higher

 

[blig-blug]

I'll give this an attempt some day. I have high CYP2D6 based on how my body responds to opioids and duration of activity. I've taking about a few months off of taking caapi tea daily in the morning myself. This is an interesting experience but how low a harmala dose will it work with?
200mg harmala is usually enough to activate dmt for me. 8g seeds is like 300-400mg so not too much higher

The person reporting having used 8g seeds reports very high rue doses usually. 8g would be way too much for most people. I wouldn't go past 4g on a first attempt.

 

[Sabnock1990]

Yes. To be fair I have been “endo-tripping” in the night my entire life. Whatever it is it is very tryptamine-like. I get sleep paralysis often and lucid dream frequently. It can happen more on nights when I’m having more sleep paralysis…but this tryptamines state happens outside of the paralysis while awake and able to move.

When I was drinking full doses of oral ayahuasca every week plus doing all that other stuff it got very weird and also unpleasant. This was not like a light DMT state though. I was having stuff happen in the night that was incredible. Once In the middle of the night I “fell” through the floor of my house and went down into the earth, into a crystalline city of advanced humans who are existing in some higher dimension or something. They gave me tours of this city, and I could literally come back to my body at will to get up go pee and then back into my bed…and then I would fall back down into this city. I could never repeat that experience. It was at least the weirdest “dream” experience I have had.

In the daytime I felt totally exhausted.

These things still happen but not to that extent.

I wonder if it's possible that 5-Methoxytryptamine is involved in some of what you've experienced, and it is apparently metabolized by MAO-A just like the other endogenous Tryptamines so with MAO-A inhibition involved (like taking Aya regularly) i'm guessing it's a possibility, and also can occur from N-deacetylation of Melatonin (as well as by the ASMT enzyme from O-methylation of Serotonin).

 

[Sabnock1990]

The person reporting having used 8g seeds reports very high rue doses usually. 8g would be way too much for most people. I wouldn't go past 4g on a first attempt.

Yeah i as well generally don't recommend more than 4 grams of Rue, it's plenty, if one wants it to get even stronger just take 4 grams daily or a few times a week and it'll get heavy duty strong in no time lol.

 

[Sabnock1990]

I'll give this an attempt some day. I have high CYP2D6 based on how my body responds to opioids and duration of activity. I've taking about a few months off of taking caapi tea daily in the morning myself. This is an interesting experience but how low a harmala dose will it work with?
200mg harmala is usually enough to activate dmt for me. 8g seeds is like 300-400mg so not too much higher

Whatever Harmala dosage you typically use for oral DMT activation should suffice, for all practical purposes treat/approach Tryptamine as you would DMT, so use an effective dosage of Harmalas for as much gut MAO-A inhibition as you can get, and then when your gut MAO-A inhibition has reached it's peak so you have peak gut MAO-A inhibition where it's maximally inhibited, take the Tryptophan+P5P B6+Methylcobalamin B12 (with or without some Methylfolate - no more than 400 to 600mcgs per day of the Folate, imo, as too much Methylfolate will use up too much B12 and can reduce the chances of this working, ime), and so long as everything goes right it should work. And so whatever timeframe you use for when to take DMT should work, an hour into the Harmalas is the perfect time for me to take oral DMT so that's when i take the Tryptophan+B's, though for you if you have higher CYP2D6 levels the timeframe might be between say 10 to 20 to 35 minutes apart, maybe? But usually i'd say whenever you take the oral DMT, that's when you should take the Tryptophan+B's but i recommend making sure you give the Harmalas enough time to kick in properly and reach peak gut MAO-A inhibition and that's the best time to take it.

 

[harmala_afficianado]

if one wants it to get even stronger just take 4 grams daily or a few times a week and it'll get heavy duty strong in no time lol.

I was taking 4 grams daily during the first 1-2 months when i first started using rue, i thought i got everything i needed until i jumped to 7-8g and realized rue has ALOT more to offer.

 

[Jamie01]

Whatever is going on I bet you can kickstart it as well without taking anything and just darkrooming but obviously taking stuff enhances it. When I was a kid I def saw DMT type patterns in the dark at night already. To this day I can close my eyes any time I want and usually see very faint mandalas/fractals…esp if I close my eyes and look at the sun. The brain is clearly able to trip on its own from my perspective. I suspect perhaps I am a low MAO-A genotype since I am really sensitive to these tryptamines anyway. I never have issues activating oral DMT even with under 2 grams of rue.

Back around like 2010-2013 maybe I was into taking harmalas like twice a day probly..doses of melatonin like 25mg sometimes. Plus diet stuff. I also had a lot of vertigo back then not realizing I had an auto immune disease. I would have vertigo and lay there eating harmalas in the daytime likely helping me to feel disoriented. I have noticed more recently that if I feel that way and go lay down esp while stoned it’s a bit fever dreamish. All these things likely contributed to whatever I experienced back then. The weirdness lasted 2-3 months before “normalizing” back to the baseline weirdness.

 

[harmala_afficianado]

Whatever is going on I bet you can kickstart it as well without taking anything and just darkrooming but obviously taking stuff enhances it. When I was a kid I def saw DMT type patterns in the dark at night already. To this day I can close my eyes any time I want and usually see very faint mandalas/fractals…esp if I close my eyes and look at the sun. The brain is clearly able to trip on its own from my perspective. I suspect perhaps I am a low MAO-A genotype since I am really sensitive to these tryptamines anyway. I never have issues activating oral DMT even with under 2 grams of rue.

Back around like 2010-2013 maybe I was into taking harmalas like twice a day probly..doses of melatonin like 25mg sometimes. Plus diet stuff. I also had a lot of vertigo back then not realizing I had an auto immune disease. I would have vertigo and lay there eating harmalas in the daytime likely helping me to feel disoriented. I have noticed more recently that if I feel that way and go lay down esp while stoned it’s a bit fever dreamish. All these things likely contributed to whatever I experienced back then. The weirdness lasted 2-3 months before “normalizing” back to the baseline weirdness.

Would you say you benefited from it? Or was it just weird and interesting?

 

[Sabnock1990]

I was taking 4 grams daily during the first 1-2 months when i first started using rue, i thought i got everything i needed until i jumped to 7-8g and realized rue has ALOT more to offer.

Yeah it's likely coming from the background compounds most likely, although i have noticed over the years that it seems like when using lower dosages of Rue/Harmalas that while it still builds up the reverse tolerance and thus the Harmala content gets stronger, it almost seems like the Harmalas are lighter in comparison to higher dosages of Harmalas, and while the reverse tolerance does build up more slowly/weakly with lighter Rue/Harmala dosages and faster/more strongly with higher dosages of Rue/Harmalas, i notice i tend to feel higher dosages more strongly even though even though i get to the same level as the reverse tolerance builds up with lighter dosages but the Harmala feel/effects seem lighter in comparison to higher dosages, if that makes sense. It could be that certain dosages of Harmalas have more of an impact and is separate from the reverse tolerance mechanism, maybe.

But the background compounds definitely contribute as you increase the dosage of Rue, and i think the effects of the background compounds may be what you're experiencing. I myself have taken like 7 grams up to 10 grams, sometimes all at once, sometimes spaced out over the day by taking the Rue 2 to 3 times a day, but of course my body is already used to the Harmala content of the Rue so the main thing i notice from higher dosages is the increase in the level of the background compounds while the Harmala content stays pretty clean and the background compounds most definitely have things to contribute that you don't seem to get from the more common dosage range.

Also one thing to think about and try out is adding admixture plants to the Rue, you don't have to add DMT or another Psychedelic, you can add various different kinds of plants to it in order to alter/shift/change/add to/enhance and reduce side-effects of the Rue, you can "flavor" it in various ways and add elements which contribute to the different kinds of medicine that can be made with Rue. It's definitely worth exploring. I'm sure you've seen my mentions of Lemon Balm and ime it's worth trying out a 3 to 4.5 gram dried Lemon Balm leaf tea with the higher dosages of Rue, it'll help clean things up a good bit and helps the Rue feel better but also adds a nice flavor and character to it and adds some extra benefits, definitely check it out if you haven't already. But Lemon Balm is just one possible admixture plant, there are thousands and hundreds of thousands of plants in Nature which could be tried out as admixture plants with the Rue (or even the Caapi, as well as Harmala extracts), and on top of that you could even mix different plants together in combination with the Rue and make a cool unique recipe. There's so much potential there imo/ime, that most people don't really even think about, like they'll take just the Rue and think that's all there is to it, but if you really get into it and start mixing things together, you can create some really cool blends.

 

[harmala_afficianado]

although i have noticed over the years that it seems like when using lower dosages of Rue/Harmalas that while it still builds up the reverse tolerance and thus the Harmala content gets stronger, it almost seems like the Harmalas are lighter in comparison to higher dosages of Harmalas

Tbh, after using 8g+ daily for months, now 5g gives me what i wanted from 8g+ when it didn't before, it almost seems like theres a permanent effect from taking 8g+ for a long time and now lower amounts are enough.

But the background compounds definitely contribute as you increase the dosage of Rue, and i think the effects of the background compounds may be what you're experiencing. I myself have taken like 7 grams up to 10 grams, sometimes all at once, sometimes spaced out over the day by taking the Rue 2 to 3 times a day, but of course my body is already used to the Harmala content of the Rue so the main thing i notice from higher dosages is the increase in the level of the background compounds while the Harmala content stays pretty clean and the background compounds most definitely have things to contribute that you don't seem to get from the more common dosage range.

Interesting, do you have more info about the background compounds, how do you think they contribute? I always thought it was mainly just the harmaline and harmine even at higher amounts.

Also one thing to think about and try out is adding admixture plants to the Rue, you don't have to add DMT or another Psychedelic, you can add various different kinds of plants to it in order to alter/shift/change/add to/enhance and reduce side-effects of the Rue, you can "flavor" it in various ways and add elements which contribute to the different kinds of medicine that can be made with Rue. It's definitely worth exploring. I'm sure you've seen my mentions of Lemon Balm and ime it's worth trying out a 3 to 4.5 gram dried Lemon Balm leaf tea with the higher dosages of Rue, it'll help clean things up a good bit and helps the Rue feel better but also adds a nice flavor and character to it and adds some extra benefits, definitely check it out if you haven't already. But Lemon Balm is just one possible admixture plant, there are thousands and hundreds of thousands of plants in Nature which could be tried out as admixture plants with the Rue (or even the Caapi, as well as Harmala extracts), and on top of that you could even mix different plants together in combination with the Rue and make a cool unique recipe. There's so much potential there imo/ime, that most people don't really even think about, like they'll take just the Rue and think that's all there is to it, but if you really get into it and start mixing things together, you can create some really cool blends.

100%, you can definitely increase rue's potential with other plants, i have tried alot lol, you can check out my posts:

Post in thread 'Amazing harmala combinations you should try'

May 28, 2026

Sooo… here's a few coleus seedlings finally sprouting after a recent warm spell. Seems they like a bit of warmth to get going.
View attachment 109610View attachment 109611View attachment 109612
I swept up the sand where'd I dropped some seeds on the slabs in my conservatory and scattered it into the seed tray after filling tie cells with seed compost. Looks like it could do with a few more perhaps, although I'll prick out the larger ones into their own cells soon.

Maybe autumn will provide a harmala combo out of this - speaking of which:View attachment 109613
the rue plant seems pretty happy. It's great to have yet another...

• harmala_afficianado

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Thread 'Coleus blumei and syrian rue'

May 28, 2026

Im a daily harmala user, and ive been experimenting with alot off not well known plants to combine with rue, recently, i got some coleus leaves as i heard that certain species contain some salvinorin, and turns out the one i got had some salvinorin (im pretty sure), at first i started with 2-3 leaves, and it wasnt very hallucinogenic, but i was more sensitive to light and sound, music sounded really really good, almost heavenly, and i felt unusually clear headed, like no thoughts in my head, it was like i was isolated in a huge space, which was my mind.


The second day i took about 5-8...

• harmala_afficianado
• Replies: 19
• Forum: Harmalas

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I have tried lemon balm with rue at the beggining, but tbh one of if not the main aspect i like about the rue is the stimulant effect, i find lemon balm and other gabaergics to somewhat smooth it out, although i have found that valerian root can boost some aspects of the rue, like visuals and introspection.

I really recommend you try lions mane, it really goes hand in hand with rue and really adds depth to it, and massively increases the benefits, ime.

I also find nutmeg or mace to go really nicely with rue, i even somewhat enjoy it more than cannabis+rue, i picked up some cannabis a month or two ago after stopping for years, i smoked daily for like a month and stopped like a few weeks ago, i find cannabis increases the "wisdom teaching" effect of rue, and also cannabis seems to have a reverse tolerance when rue is taken daily with it, nutmeg+rue on the other hand for me is mostly just an enjoyable euphoric mix, and tolerance builds instantly so i mostly take it once every 1-2 weeks, nutmeg is more consistantly enjoyable for me than cannabis but cannabis can definitely be more medicinal, both with the rue ofc.

I have also found saffron threads to be a nice addition to the rue, but it somewhat blunts the spiritual effect of rue and just makes the experience more euphoric, i use it every once in a while when i just want to be social or just enjoy myself.

But out of all the combos i tried, lions mane is the best daily companion with rue, ime, it is also ime essential if your trying to get the most out of cannabis+rue, i was eating the mushroom the whole time when i was smoking.

 

[Jamie01]

Would you say you benefited from it? Or was it just weird and interesting?

No I wouldn’t say I benefited. I don’t know what to say about it aside from it changed my views on reality. I don’t know what to believe but I am convinced whatever it is astral projection is real.

 

[harmala_afficianado]

No I wouldn’t say I benefited. I don’t know what to say about it aside from it changed my views on reality. I don’t know what to believe but I am convinced whatever it is astral projection is real.

How would you say your view of reality changed? Interesting though, i do not like the psychoactive effects of melatonin but you got me really interested, i think ill try it with a high amount of rue.