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Harmala Alks / MAOI's

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idtravlr

idtravlr

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Hey guys - Not sure if this thread 100% belongs here, but I think it generally fits in. Can someone please answer a question for me? Are the Harmala, Harmaline, and THH alkaloids that exist in b. caapi, syrian rue, and other entho plants actually the MAOI's themselves, or are the MAOI's in the plant separate from the Harmalas?
Bottom line of my question is this: If one was to extract pure Harmala alkaloids, would they have a pure psychoactive substance, or would they have an MAOI that has psychoactive properties? In short, do pure Harmala alkaloids require an MAOI type of diet before ingesting?

Thanks in advance for your input.

Regards,
-idt
 
Let's ask the Oracle..

69ron said:
Tyramine is destroyed by MAO-A enzymes in the digestive system. Food high in tyramine is dangerous to consume when taken normal MAO-A inhibitors because they permanently destroy the MAO-A enzymes allowing tyramine to pass right through for many days. That leaves your body very vulnerable and you can actually die from it.

The harmala alkaloids are a little different from the typical MAO-A inhibitors. The harmala alkaloids do not destroy MAO-A enzymes, they only temporarily bind to them, making them inactive for just a few hours. This means the harmala alkaloids are reversible MAO-A inhibitors, because they only temporarily bind to MAO-A and don’t actually destroy them like many other MAOIs do. Because of this, the harmala alkaloids are classified as RIMA compounds and not full MAOI compounds.

Tyramine is able to displace harmine, harmaline, and THH, causing them to be freed from the MAO-A enzymes, so that the tyramine is then destroyed by the MAO-A enzymes and rendered inactive. Because tyramine is still rendered inactive under the effects of harmine, harmaline, and THH, there is no need for any dietary restrictions. This is true for all RIMAs. However, complex drug interactions can occur with RIMAs and can be fatal. So while it’s safe to eat pretty much any type of normal food, taking medicinal herbs with RIMAs could be dangerous. And some foods contain drugs that normally are inactivated by MAO-A, but become active while taking a RIMA. For example, a salad made from chacruna leaves would not do anything to you normally, but if a RIMA was taken, the DMT in the leaves would become active. No one knows how many possible food items contain such drugs that might become active under the effects of a RIMA. So far, no normal food items have been shown to contain such drugs so there is no RIMA diet.
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THANK YOU smokeydaze!!! Exactly the information I was looking for! :D I guess I could have searched a little deeper myself, but thank you for helping out, regardless of my laziness! ;)

69ron - Thank you for this information, and your contributions to this site! This site just has such an absolutely amazing community. Great people with great intentions all the way around...

Happy Travels,
-itd
 
does anyone know about smoking the harmala salts?? I smoked rue before and had some effects but is the freebase better for this method of administration? I just finished an extraction on rue, salting out the harmalas from the acid water with rock salt..it worked great!..but I have yet to base them(or clean them up) and I want to use them for changa..
 
I think I've heard of people having success with smoking them, only one way to find out.

How were you thinking of using haramala salts for Changa?
 
well for now I was just going to throw mix it in with my changa when I pack the bowl..cant use iso..are freebase harmalas soluble in naptha and limonene?
 
I think sublingual haramala in conjunction with the changa is the most appropriate method, what leafs are in your changa?
 
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