Sabnock1990
Be Your Own Shaman
Not sure, i haven't worked enough with Harmine yet, and haven't tried Harmine with DMT, to see what the dosage would be for full MAO-A inhibition. I've always either used 3 to 4.5 grams of Rue seed powder, or 180 to 200mgs of freebased Rue or freebased Harmala extract, any less wasn't strong enough ime. Just go for 150 to 180mgs of Harmaline and see how that does, 100mgs is probably on the light end in terms of MAO-A inhibition. I don't even get any nausea or vomiting from the extracts unless i go over 200mgs, and even then i don't really get any nausea but i do sometimes still vomit, 180mgs seemed like a sweet spot dose for me.
Also take into consideration that some people have higher or lower amounts of MAO-A that needs to be inhibited, and they are metabolized by CYP2D6 so some people may need more or less. Aside from that, there's the timing thing where you take the Harmalas first and wait a certain amount of time to take the DMT, so might need to play around with the timing a little bit, 30 minutes to an hour always seemed to do fine for me when using Rue seed powder or freebased extracts in capsules, some say it's fine to take them at the same time but it's a bit more inconsistent that way from what i've seen online whereas i've rarely ever had an issue taking the DMT 30 minutes to an hour after the Rue/Harmalas. But as long as you get the Harmala dosage right and get the timing between the Harmalas and DMT right, it'll definitely work.
Also take into consideration that some people have higher or lower amounts of MAO-A that needs to be inhibited, and they are metabolized by CYP2D6 so some people may need more or less. Aside from that, there's the timing thing where you take the Harmalas first and wait a certain amount of time to take the DMT, so might need to play around with the timing a little bit, 30 minutes to an hour always seemed to do fine for me when using Rue seed powder or freebased extracts in capsules, some say it's fine to take them at the same time but it's a bit more inconsistent that way from what i've seen online whereas i've rarely ever had an issue taking the DMT 30 minutes to an hour after the Rue/Harmalas. But as long as you get the Harmala dosage right and get the timing between the Harmalas and DMT right, it'll definitely work.