Recent Salvinorin Research

[T.Harper]

links to recent Salvinorin A / KOR Agonist infos
Please add to this thread also if you stumble across anything.
Would be nice and useful to keep this thread just for links and not for conversations


Time course of pharmacokinetic and hormonal effects of inhaled high-dose salvinorin A in humans

http://jop.sagepub.com/content/30/4/323

Highly selective non-opioid kappa opioid receptor (KOR) agonist salvinorin A protects against forebrain ischemia-induced brain injury in rats.

Highly selective non-opioid kappa opioid receptor (KOR) agonist salvinorin A protects against forebrain ischemia-induced brain injury in rats - PubMed

SA protects against I/R-induced brain injury by attenuating brain edema formation and inhibiting neuronal death and improves neurologic recovery of rats post-I/R.

www.ncbi.nlm.nih.gov

Naltrexone but not ketanserin antagonizes the subjective, cardiovascular and neuroendocrine effects of salvinorin-A in humans

https://www.researchgate.net/publication/294421177_Naltrexone_but_not_ketanserin_antagonizes_the_subjective_cardiovascular_and_neuroendocrine_effects_of_salvinorin-A_in_humans

 

[T.Harper]

Relative Timing Between Kappa Opioid Receptor Activation and Cocaine Determines the Impact on Reward and Dopamine Release.

Relative Timing Between Kappa Opioid Receptor Activation and Cocaine Determines the Impact on Reward and Dopamine Release - PubMed

Negative affective states can increase the rewarding value of drugs of abuse and promote drug taking. Chronic cocaine exposure increases levels of the neuropeptide dynorphin, an endogenous ligand at kappa opioid receptors (KOR) that suppresses dopamine release in the nucleus accumbens (NAc) and...

www.ncbi.nlm.nih.gov

 

[Cognitive Heart]

Highly selective non-opioid kappa opioid receptor (KOR) agonist salvinorin A protects against forebrain ischemia-induced brain injury in rats.

Highly selective non-opioid kappa opioid receptor (KOR) agonist salvinorin A protects against forebrain ischemia-induced brain injury in rats - PubMed

SA protects against I/R-induced brain injury by attenuating brain edema formation and inhibiting neuronal death and improves neurologic recovery of rats post-I/R.

www.ncbi.nlm.nih.gov

Wow! Great stumble. Thanks for sharing. Will contribute if I come across something of worth. :thumb_up: