RoundAbout said:
Jagube said:
Also, if the indigenous people had not discovered these plants, we would have. They discovered them first, because they grew in their area.
I doubt that, for instance, we would be aware of
Salvia divinorum, and therefore salvinorin A (which if I recall correctly is more potent than the previously known KOR agonists, with a much different structure and pharmacokinetics). There has been a fair amount of speculation (with favourable evidence) that it was preserved only through cultivation by the Mazatec. Despite the Mazatec providing it to researchers, it took ages to figure out the active compound... I believe there was even speculation that it was actually inactive.
Who is defined here by "we"? Are we referring to western culture as a whole? What defines the "West" at this point? Clearly it's not a geographical location, even though we could discuss it's many euro-centric origins...still, whatever that we is it comprises traits from cultures around the globe, because we are talking about a global culture of people, from around the globe. This is the reality we live in.
Look at all the plants we did find. We discovered ergot. Multiple cultures, including european, likely discovered psilocybin mushrooms over and over again. We found datura, henbane, amanita muscaria. MDMA, ketamine, LSD, 2cb, 2ce, DMT, 5-MeO-DMT...all discovered within the context of a laboratory, before any of us had knowledge of these things existing elsewhere or current contexts of use.
The whole thing is just too open ended to put a cap on. Salvinorin A was discovered in the west yes because the Mazatec people allowed others to come in and study it. People in Mexico will still want to study all the plants that grow there. They have botanists. This is however, pointless speculation.
We also know what salvinorin A is, and that you can vaporize it, because of all the work Daniel Siebert did. That opened the door for a lot of people to come in and study it receptor affinity. This is a huge part of why we understand what we do about salvinorin A. From one anglte(not one I care to stand by), I could argue that we know a lot more about this compound than the Mazatec do.
Now, the situation has deepened. Because of science following...leads...we understand that salvinorin A is found in Salvia recognita, Salvia cryptantha and Salvia glutinosa. If we wanted a theraputic model involving organic salvinorin A, we would not even need Salvia Divinorum.
It leaves us again in the middle of some process, with ill defined borders.
This is a bit of a sidetrack still, as most of the attention at the moment seems to be on MDMA, ketamine, LSD and psilocybin. I know some here in Canada are looking at 2cb for the future. The exception of iboga ,peyote and bufo venom...and a lot of that is underground new agers as well. People eating peyote they did not grow at this time is a problem I feel that should be discussed.
Mining should be discussed because it IS effecting peyote. A lot of that mining money is thrown into the budding psychedelic market. This is most certainly an issue.