I know i commented on here 4 years ago, but there's been an update. I believe that at least the paranoia and anxiety from Cannabis is related to Folate/B12 deficiency, likely moreso Folate deficiency, ime. I used to respond well to Cannabis for the first couple years, then it started getting a bit weird on me, i thought it was because of the Aya experimentation and so i kept smoking Cannabis for 10 years straight, i ultimately had to quit because it was just too much psychologically-speaking, and like a few months later i found Delta 8 and HHC and stuck with that ever since. Since then though, i have gotten back to smoking Cannabis again here and there, and when i first started back i was still getting some anxiety and paranoia, but around the same time i started reading into Folate and gave Methylfolate a try (sometimes with Folinic Acid in the mix as well) and of course added in B12, and ever since the anxiety and paranoia seems to have gone away. It seems moreso correlated to Folate, however i think B12 may contribute and B12 deficiency has been linked to paranoia and anxiety, but B12 and Folate work together and ime it's the Folate (particularly the Methylfolate) that helps with the paranoia and anxiety. I am very certain that it is related to lack of Folate/B12 (particularly Folate) and i definitely notice the differences and the impact that supplementing with proper Folate has had, not just with Cannabis but generally. Also, might want to avoid Folic Acid as much as possible, or at least try not to over-indulge as it can cross into the bloodstream unmetabolized and cause problems, including blocking the Folate Receptor Alpha and transport of Methylfolate, as well as Tetrahydrobiopterin.