Endogenous Psychoactive Tryptamines Reconsidered - An Anxiolytic Role For Dimethyltryptamine (DMT) | PDF | Hallucinogen | Serotonin
"A contemporary investigation, utilizing modern
genetic and structural techniques, has provided a
more detailed analysis of INMT, but does not provide
a complete story. In two studies, Thompson
et al. [35,36], cloned, expressed, localized, and
characterized the activities of rabbit and human
INMT. Using Northern blot analysis, they found rabbit
INMT transcripts expressed heavily in the lung,
moderately in the liver, and weakly in the brain.
Human
INMT was expressed in the lung, thyroid, adrenal
gland, heart, muscle, and spinal cord, but not in
the brain. The authors observe high Km values (an
order of magnitude higher than in previous studies
[33,34]) of TYP for recombinant human INMT and
an absence of INMT mRNA transcripts in the brain.
Thus, Thompson et al. conclude that the production
of DMT in humans is not physiologically significant.
Their conclusion places much weight on the significance
of observed Km values for recombinant human
INMT and does not take into account several
additional genetic and enzymatic concerns."