Spiralout
Rising Star
Interesting thoughts on the rue. Do you mean to say that it may be helping attenuate kratom-withdrawal symptoms?
I've meant to make a thread about this but I'm not sure how much I have to say that hasn't been said:
I'm still working on getting off kratom. I'm at about 17 gpd at the moment. I decided to do a slow taper, at about 1 gram less per day, but allowing myself to stay on the current dose for extra days if need be, as long as I don't up the dose.
This stuff is wicked addictive. If you think it isn't then you are delusional. It acts on mu opiate receptors as an agonist as does every other addictive opiate/opiod. The fact that the molecular structure does not contain the classic morphinian backbone (or what have you) is completely irrelevant, as is it's legality, or the fact that it is "natural". Non of that shit has any bearing on it's addictive nature: if you understand the slightest bit about neurochemistry, you realize that the receptor activity a substance/material has is the primary relevant factor when assessing effects and addiction liability etc. Plus, there's more than enough anecdotal reports and medical literature on it's addictive nature.
This isn't to say it should be demonized. Our relationship with drugs is context dependent and finding a framework to encase our thinking on our relationships to drugs requires nuance and wisdom, and we are still finding our way as a species as to how to think about this. Our society is full of addictions, and we have not yet the wisdom to deal with it. I think we're getting there though.
I've meant to make a thread about this but I'm not sure how much I have to say that hasn't been said:
I'm still working on getting off kratom. I'm at about 17 gpd at the moment. I decided to do a slow taper, at about 1 gram less per day, but allowing myself to stay on the current dose for extra days if need be, as long as I don't up the dose.
This stuff is wicked addictive. If you think it isn't then you are delusional. It acts on mu opiate receptors as an agonist as does every other addictive opiate/opiod. The fact that the molecular structure does not contain the classic morphinian backbone (or what have you) is completely irrelevant, as is it's legality, or the fact that it is "natural". Non of that shit has any bearing on it's addictive nature: if you understand the slightest bit about neurochemistry, you realize that the receptor activity a substance/material has is the primary relevant factor when assessing effects and addiction liability etc. Plus, there's more than enough anecdotal reports and medical literature on it's addictive nature.
This isn't to say it should be demonized. Our relationship with drugs is context dependent and finding a framework to encase our thinking on our relationships to drugs requires nuance and wisdom, and we are still finding our way as a species as to how to think about this. Our society is full of addictions, and we have not yet the wisdom to deal with it. I think we're getting there though.
Let me know what you think. The difference is like night and day. l-isomer replenishes endogenous dopamine and norepinephrine levels, d-isomer inhibits metabolism of enkephalins (beta endorphins).