Experience with @sabnock1990 discovery about tryptophan+b6 and b12+rue

[Voidmatrix]

Could certainly be true, maybe it's a molecule similar to DMT we know nothing about , it sure does produce a psychedelic tryptamine though, wether DMT or not.

I wonder if it has to be a molecule at all.
I have some pretty wild experiences sober on my shakti mat.

One love

 

[Sabnock1990]

Also it's worth mentioning that i've gotten some of the same reactions/responses/effects from this method as i've gotten from exogenous DMT, even things like microbiome influence as well as after-effects of receptor stimulation (like DMT's Alpha 1 Adrenergic receptor stimulation). It literally gives the same kind of response and benefits as exogenous DMT.

I guess i consider myself lucky that i've been able to notice how DMT affects me and then see the same thing in endogenously synthesized DMT.

 

[Sabnock1990]

I wonder if it has to be a molecule at all.
I have some pretty wild experiences sober on my shakti mat.

One love

I'm sure some folks can have some wild experiences sober, especially doing yoga or what not, but i personally have never experienced what DMT gives me while i'm sober. I have a pretty consistent sober physiology, things don't really ever change much if at all for me during soberness, it's not until i take something active that i feel a shift/difference in my physiology. Though i haven't tried things like breathwork or yoga/meditation, i just take plants lol.

 

[Sabnock1990]

Also i'd like to mention again that if anyone is into breathwork practices, try doing this method and then doing some breathwork. It's said INMT is also found in the lungs, and if you take this stuff and get the endogenous Tryptamine/NMT synthesis, doing breathwork might increase the activity of INMT in the lungs and may generate/synthesize/produce a greater amount of endogenous DMT. Seems plausible to me.

 

[Voidmatrix]

I'm sure some folks can have some wild experiences sober, especially doing yoga or what not, but i personally have never experienced what DMT gives me while i'm sober. I have a pretty consistent sober physiology, things don't really ever change much if at all for me during soberness, it's not until i take something active that i feel a shift/difference in my physiology. Though i haven't tried things like breathwork or yoga/meditation, i just take plants lol.

I try to run the gamut, and what i am learning is that psychedelics and psychoactives may help us see a capability and capacity to have these experiences on our own, and we can leverage them to accelerate our path, as well as to attenuate our system to enter certain states and elicit certain experience.

But I don't know anything.

One love

 

[harmala_afficianado]

I wonder if it has to be a molecule at all.
I have some pretty wild experiences sober on my shakti mat.

One love

It makes more sense that tryptophan is being converted to a tryptamine, wether DMT or not

 

[Voidmatrix]

Why does it make more sense objectively and not just to you?

One love

 

[harmala_afficianado]

Yup. Personally i try to scour the research and do my studying, and then gain understanding on things i feel or observe or experience and see how they correlate. For me feeling is a great way to understand what's going on in the body/brain, i just know not everyone is as scientific about it as i am and so people can have placebo effects and may mistake something for something else, feeling can be tricky but it can teach a lot to those who pay attention and know how to connect dots and know the mechanisms and such.

Yeah, that's why they say if you know yourself you will know god, and if you know god you will know everything.

 

[harmala_afficianado]

Why does it make more sense objectively and not just to you?

One love

Because it happens after very specific things, and judging by these specific things it's not that hard to conclude.

 

[Sabnock1990]

It makes more sense that tryptophan is being converted to a tryptamine, wether DMT or not

Yeah this happens at the very least, regardless if NMT/DMT are synthesized or not, the Tryptophan will decarboxylate to Tryptamine and at the very least Tryptamine will be felt/experienced so long as there is proper MAO-A inhibition and the B6 is taken with the Tryptophan. The NMT/DMT aspect seems to rely solely on available SAM via the Methylcobalamin/B12 and Methylfolate. So even if one is deficient in B12 or Folate or is low in SAM/methylation, they will still be able to get the Tryptamine at the very least.

 

[Voidmatrix]

Because it happens after very specific things, and judging by these specific things it's not that hard to conclude.

Can you be more specific? I could say the same thing in the same way about almost anything. What happens after what things and what is the valid or sound logic that makes it hard not to conclude?

I encourage us all to look at our fanaticism and attachment to novelty in our attributions of what may or may not be a result of DMT.

One love

 

[Sabnock1990]

Why does it make more sense objectively and not just to you?

One love

To me it makes sense objectively (as opposed to purely subjectively) because the science is there on the mechanisms/metabolic processes and nutrients, and then there's what we know and think we know so far about DMT's endogenous synthesis, and so like harmala_afficianado said, it's not hard to conclude what's going on, especially when you not only understand the internal processes but can also actively feel the differences and correlate them with past experience and familiarity with DMT. DMT to me is a very unique compound (though i'd say pretty much all compounds are unique and it's not hard to tell them apart), i for one wouldn't be a good subject for placebo controlled trials lol, i'd be able to tell if i'm taking a particular compound vs placebo.

 

[northape]

Yeah, that's why they say if you know yourself you will know god, and if you know god you will know everything.

I'm pretty sure knowing yourself implies knowing the nature of the mind. You see how the mind works, and slowly penetrate to deeper layers, where there is no difference between the mind and anything else. Working with the body can be useful (fasts, pranayama, etc.), yet these are just supporting practices. The Mind is King

 

[harmala_afficianado]

Can you be more specific? I could say the same thing in the same way about almost anything. What happens after what things and what is the valid or sound logic that makes it hard not to conclude?

I encourage us all to look at our fanaticism and attachment to novelty in our attributions of what may or may not be a result of DMT.

One love

It happens after taking tryptophan+rue+b12 and b6, it doesn't happen with rue alone nor rue+tryptophan nor rue+b12 and b6, and science supports this idea more than it disproves it, what else is more likely to be the conclusion?

 

[Sabnock1990]

I'm pretty sure knowing yourself implies knowing the nature of the mind. You see how the mind works, and slowly penetrate to deeper layers, where there is no difference between the mind and anything else. Working with the body can be useful (fasts, pranayama, etc.), yet these are just supporting practices. The Mind is King

That's another part of it, when you know yourself, when you are in tune with the body and mind, you can see more deeply how the body and mind works/functions, and you can gain deeper insight into what's going on. Harmalas, DMT, and as well as Cannabis, for example, tend to help me tune into the body and mind more deeply and then i can see what's going on internally, and so far i have been pretty spot on with what i've gained from insight/intuition (backed by studies and research as well so i'm not flying blind), and i'm pretty good at discerning and understanding things about the body and mind.

 

[Voidmatrix]

what else is more likely to be the conclusion?

Wrong question, and why @blig-blug mentioned falsifiability.

One love

 

[harmala_afficianado]

I'm pretty sure knowing yourself implies knowing the nature of the mind. You see how the mind works, and slowly penetrate to deeper layers, where there is no difference between the mind and anything else. Working with the body can be useful (fasts, pranayama, etc.), yet these are just supporting practices. The Mind is King

The mind is king only for people who choose a certain path, it is a curse for others, so technically your mind alone isn't king.

 

[Sabnock1990]

And not only is it not hard to conclude what's going on, it's easy to connect the dots of all these things coming together leading to DMT, even with how DMT affects me personally and noticing the same things from it's endogenous synthesis. When all the evidence leads towards a particular conclusion/understanding, chances are the theory (rather than mere hypothesis) is correct. The minute some data comes along that doesn't align with the rest of the evidence, then one can talk about exploring other alternative hypotheses imo, but why go against the evidence when the evidence is leading towards a clear-cut conclusion? I understand one has to pull out all the stops and make sure there's nothing else possibly going on there, but i think the obvious should be explored first before trying to fit square pieces into a round hole.

 

[Voidmatrix]

Last note and I'll leave it alone.

Good science concerns itself with how an idea may be wrong, not with building up an unfalsifiable context to strengthen the claim. That's world building, not science.

One of the best ways to check the validity of an argument is the short truth table method, where you try and see if you can set up a given argument to be invalid (true premises and a false conclusion). If you can, the argument is invalid. This is the logical mirror for empirical falsifiability.

One love

 

[northape]

That's another part of it, when you know yourself, when you are in tune with the body and mind, you can see more deeply how the body and mind works/functions, and you can gain deeper insight into what's going on. Harmalas, DMT, and as well as Cannabis, for example, tend to help me tune into the body and mind more deeply and then i can see what's going on internally, and so far i have been pretty spot on with what i've gained from insight/intuition (backed by studies and research as well so i'm not flying blind), and i'm pretty good at discerning and understanding things about the body and mind.

I agree with you and put my subjective experience before anything else, too. That's all we have in the end. Still, personal bias is a real thing, and you should always question yourself.

The mind is king only for people who choose a certain path, it is a curse for others, so technically your mind alone isn't king.

Hmm, not really. We just use different labels, but reality is still the same. What's called God in Abrahamic religions is the Mind in Buddhism, for example.