Experiments with MaoB inhibition

[Key Omen]

This is an interesting topic if anyone can shine some light from experience. Has anyone tried a plant like Ceiba or Fava d'anta? What are the dynamics, are these only effecting the gut or is MAOB in the brain as well? Is it possible Ayahuasca can last for a steady week long? I wouldn't want to figure this one out the hard way. Good to know for information purposes only I guess.

noticed this short list (J. Ott is a source for much more)

Cordyseps sinensis, a chinese fungu. reversible or not?
Farnesylacetone, on tabbacco reversible IMAO B. ( IMAO A= 2,3,6-trimethyl-1,4-naphthoquinone)
Anthraquinone on aloë-emondin.
Camellia Sinensis Green Tea, Black Tea, White Tea, Oolong Tea Catechin, Epicatechin MAO-B
Fallopia Japonica Japanese Knotweed Emodin MAO-B
Geijera Parviflora Australian Willow MAO-B
Olea Europaea Olive Oil Hydroxytyrosol MAO-B
Paeonia Suffruticosa Cortex Moutan, Mudanpi, Peony Paeonol MAO-A/MAO-B
Piper Methysticum Kava Kava Desmethoxyyangonin, Methysticin MAO-B
Piper Longum Long Pepper Piperine MAO-B
Piper Nigrum Black Pepper Piperine MAO-B
Polygonum Multiflorum Fo-Ti Emodin MAO-B
Rheum Emodi Rhuharb Emodin MAO-B
Uncaria Tomentosa Cat's Claw Catechin, Epicatechin MAO-B

and from wiki wiki
Selective MAO-B inhibitors

Catechin (found in the Tea plant, Cocoa, and Cat's claw)
Desmethoxyyangonin (found in Kava)
Epicatechin[30] (also found in the Tea plant, Cocoa, and Cat's claw)
Emodin[31] (found in Fo-Ti)
Hydroxytyrosol (found in Olive oil)
Piperine[31] (found in Pepper)
Gentiana lutea[32] (active constituent(s) unknown)

 

[Global]

I know you asked for someone with experience. Unfortunately, I have none and I am going to venture that most here won't, but from what I understand is that even if inhibiting MAOB will make DMT orally active, it wouldn't have nearly the same dynamics as with harmalas. In terms of ayahuasca lasting for a week, it's interesting to note in my experience with regular ayahuasca that the DMT plant usually wears off before the harmalas. Therefore I might assume that even if you were to stretch MAO inhibition over the course of a week (or more) that the DMT part of the ayahuasca would wear off rather quickly in comparison (but of course you could always just take more DMT). I'm trying to be as respectful as possible when I say that I would question the safety of MAOB inhibition with oral DMT as well.

 

[endlessness]

Seems unsafe in significant doses, because MAO-B inhibition would mean that you'd need to really restrict your diet, and also doesn't sound effective because DMT is primarily metabolized by MAO-A.

Also IIRC DMT also is metabolized secondarily by some CYP enzymes, which is also I think why DMT is eventually metabolized even if you have enough harmalas in your system. There has been some talk of inhibiting that enzyme too, I think, but that could be dangerous to inhibit two key metabolism enzymes at once in significant amounts, because your body is processing not only DMT but a bunch of other substances that you've been consuming and that your body itself generates.

If you want a week-long ayahuasca session, why not keep drinking? The taste and possible nausea/purging and physical symptoms is the price the warrior has to pay to join the gods, and a small one imo

 

[Key Omen]

Seems unsafe in significant doses, because MAO-B inhibition would mean that you'd need to really restrict your diet, and also doesn't sound effective because DMT is primarily metabolized by MAO-A.

Also IIRC DMT also is metabolized secondarily by some CYP enzymes, which is also I think why DMT is eventually metabolized even if you have enough harmalas in your system. There has been some talk of inhibiting that enzyme too, I think, but that could be dangerous to inhibit two key metabolism enzymes at once in significant amounts, because your body is processing not only DMT but a bunch of other substances that you've been consuming and that your body itself generates.

If you want a week-long ayahuasca session, why not keep drinking? The taste and possible nausea/purging and physical symptoms is the price the warrior has to pay to join the gods, and a small one imo

I suppose that's the way, but I did read something about a red poison, thought it was a baobob relative but I can't find the reference - to a tree which has blood red sap and is dangerous if dietary precautions are not made as its effects last for a week. It was known to be an ayahuasca analogue, but I didn't see it in Ott's book this time around.. oh well. Its no problem to drink a brew a few times a day or week when its abundant.

 

[acolon_5]

FYI, Kava in large doses (krunk-ed) acts as well, if not better, than Harmine for smoking DMT. This was tested in 2 people over a few days. Very pleasant, slow, typical MAOI + smoked DMT experience...with even less anxiety than normal.

 

[VoidTraveler]

I'm no expert in this area, but from what a little bit of research tells me is that you should be careful. According to Wikipedia:

In general, Monoamine Oxidase A (MAOA) prefers to metabolize norepinephrine (NE), serotonin (5-HT), and Dopamine (DA) (and other less clinically relevant chemicals). Monoamine Oxidase B, on the other hand, prefers to metabolize Dopamine (DA) (and other less clinically relevant chemicals).The differences between the substrate selectivity of the two enzymes are utilized clinically when treating specific disorders: Monoamine Oxidase A inhibitors have been used in the treatment of depression, and Monoamine Oxidase B inhibitors are used in the treatment of Parkinson's Disease.[citation needed]

DMT is serotonin analogue, and so inhibiting MAO-B Should have little to no effect on DMT degradation.

From the same article:

This protein preferentially degrades benzylamine and phenylethylamine.[1] Like MAOA, it also degrades dopamine.

Mescaline is part of the phenylethylamine family, so it would make more sense if you wish to prolong mescaline sessions. However, I'd be extremely careful there as you're probably threading into unexplored terrain. If the natives didn't inhibit the mescaline during a trip I don't think there's a need for it or a danger to it.

But that's just all my side of things. Safe travels.

 

[tetra]

The taste and possible nausea/purging and physical symptoms is the price the warrior has to pay to join the gods, and a small one imo

Just had to highlight that line. Genius.

 

[Key Omen]

I'm no expert in this area, but from what a little bit of research tells me is that you should be careful. According to Wikipedia:

In general, Monoamine Oxidase A (MAOA) prefers to metabolize norepinephrine (NE), serotonin (5-HT), and Dopamine (DA) (and other less clinically relevant chemicals). Monoamine Oxidase B, on the other hand, prefers to metabolize Dopamine (DA) (and other less clinically relevant chemicals).The differences between the substrate selectivity of the two enzymes are utilized clinically when treating specific disorders: Monoamine Oxidase A inhibitors have been used in the treatment of depression, and Monoamine Oxidase B inhibitors are used in the treatment of Parkinson's Disease.[citation needed]

DMT is serotonin analogue, and so inhibiting MAO-B Should have little to no effect on DMT degradation.

From the same article:

This protein preferentially degrades benzylamine and phenylethylamine.[1] Like MAOA, it also degrades dopamine.

Mescaline is part of the phenylethylamine family, so it would make more sense if you wish to prolong mescaline sessions. However, I'd be extremely careful there as you're probably threading into unexplored terrain. If the natives didn't inhibit the mescaline during a trip I don't think there's a need for it or a danger to it.

But that's just all my side of things. Safe travels.

Actually I reconsidered this. An elder tells me Peyote has no known contraindications to the natives. In the morning it is common to eat many types of foods. Surely olive oil, pepper and teas are eaten occasionally. The effects are known to last a week sometimes and maybe this could be a factor.