Harmalas safety guide

[reun]

Hi all,

I'm new here, I'm planning to experiment with harmalas soon, and I was hoping that members of this forum may be able to offer some sage advice concerning harmalas safety.

While paths of administration are not the point of this thread, I thought I'll mention what I have in mind just in case it will contextualise the rest of this discussion. I'd like to try harmalas:

• Standalone: ~100 mg of harmalas to start off with, just to experience this substance on its own
• Ayahuasca: mix about 50 mg of harmalas (mixed in lemon juice) with about 80 mg of freebase DMT (also mixed with lemon juice and consumed 30 mins later)
• Changa: I'd like to try 3 mixes -- (1) 1g DMT, 1 g harmalas, 1 g herb; (2) 300 mg DMT, 1g harmalas, 1g herb; (3) 500 mg DMT, 500 mg harmalas, 1 g herb

With that out of the way, I'd like to talk about safety. As I understand it, harmalas are actually very safe on their own, but their interactions introduce a lot of potential concerns, so one has to be extremely careful with that. After looking into this, I decided that there is just no way I would be open to facilitating a harmalas session for a friend because the risk here is absolutely catastrophic. As for myself, I've constructed a bit of a cheat sheet that spells out what to avoid and for how long. However, I'm still not sure how complete or how trustworthy is this sheet, and this is where I would love your input.

Would love to hear your thoughts! At least in theory, harmalas seem to be quite a handful in terms of interactions.

 

[northape]

Hi all,

I'm new here, I'm planning to experiment with harmalas soon, and I was hoping that members of this forum may be able to offer some sage advice concerning harmalas safety.

While paths of administration are not the point of this thread, I thought I'll mention what I have in mind just in case it will contextualise the rest of this discussion. I'd like to try harmalas:

• Standalone: ~100 mg of harmalas to start off with, just to experience this substance on its own

100mg is a good starting dose. Go for it.

• Ayahuasca: mix about 50 mg of harmalas (mixed in lemon juice) with about 80 mg of freebase DMT (also mixed with lemon juice and consumed 30 mins later)

Ayahuasca is a caapi vine from the Amazon. We are talking about pharmahuasca here. Your dose of harmalas should be closer to 200mg for a strong experience.

Thread 'How to make pharmahuasca hit reliably'

Sep 29, 2018

Just thought I'd post a little tidbit. Ayahuasca generally, and pharmahuasca especially, can be hit and miss. That is, you consume it, and it may take a long time to kick in, or might not kick in at all. I have discovered a method that makes it kick in EVERY time, 100% guaranteed, no misses, full force, with equal rapidity. Here's how I do it.

With pharma, I either boil 4 grams of syrian rue seeds for 15 minutes and reduce to a shot glass of liquid (no need to grind the seeds! just boil em and you'll be good), remove the seeds and take that, OR, put 200 mg pure harmine OR 100 mg pure...

• OneIsEros
• Replies: 73
• Forum: Pharmahuasca

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• Changa: I'd like to try 3 mixes -- (1) 1g DMT, 1 g harmalas, 1 g herb; (2) 300 mg DMT, 1g harmalas, 1g herb; (3) 500 mg DMT, 500 mg harmalas, 1 g herb

Thread 'All Things CHANGA: An Essential Guide'

Feb 2, 2025

All Things CHANGA: An Essential Guide​

This is something that I’ve wanted to write up and detail for a while. My intent is to cover as many bases as possible and make this as comprehensive as possible for all those that are interested in developing a relationship with changa and for those that have already been in the fray.

Let’s start with some links:
The Art of Changa, a guide to making the perfect blends.
Confusing changa guides (how much MAOI ?)
Detailed Changa Explanation (beginner friendly)
Changa Musings
Changa - DMT-Nexus Wiki...

• Voidmatrix
• Replies: 50
• Forum: Changa

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• 

With that out of the way, I'd like to talk about safety. As I understand it, harmalas are actually very safe on their own, but their interactions introduce a lot of potential concerns, so one has to be extremely careful with that. After looking into this, I decided that there is just no way I would be open to facilitating a harmalas session for a friend because the risk here is absolutely catastrophic. As for myself, I've constructed a bit of a cheat sheet that spells out what to avoid and for how long. However, I'm still not sure how complete or how trustworthy is this sheet, and this is where I would love your input.

Would love to hear your thoughts! At least in theory, harmalas seem to be quite a handful in terms of interactions.

Harmalas are relatively safe food-wise, but you need to do proper research if you are using any medication. It is good to fast beforehand to avoid food interactions and have clean bowels. Harmalas are purgative. Safe travels.

Thread '[Harmalas] MAOI Drug Interaction Disclaimer'

May 29, 2016

WARNING: There are very dangerous interactions between any MAOIs (including harmalas) and many commonly used recreational drugs and medications, including SSRI medications (such as prozac) and stimulants (such as MDMA and other amphetamines) as well as many others. If you're taking SSRI's, do not consume MAOIs!! Do not mix stimulants with MAOIs either! Mixing stimulants or medications with MAOIs can lead to Hypertensive Crisis, Serotonin Syndrome, and even death. For a more complete list of pharmaceuticals and substances that should NEVER be taken when...

• dreamer042
• Replies: 0
• Forum: Pharmahuasca

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[new_science]

Yeah, echoing what northape pointed out, taking 50mg of harmalas is not going to inhibit your MAO enough for that DMT to work its magic.

Is that chart your work? It's way too generalized. Each medication or drug has its own half life. To make an example of one you (?) included, tramadol's half life is 8 hours. You shouldn't need to wait 2 weeks after taking tramadol before taking harmalas. If the chart isn't your own work, consider more strongly vetting your sources.

 

[Voidmatrix]

This should provide useful.

One love

 

[blig-blug]

I agree with the previous posts.

Your dose of harmalas should be closer to 200mg for a strong experience.

And, to complement that, your first dose of DMT with 200mg harmalas should be lower than 80mg. Start with 30mg or 40mg, you can always redose.

About the symptoms of serotonin syndrome or hypertensive crisis: while those indeed are symptoms of it, it's not unlikely that you will experience some of them as normal effects of Ayahuasca, and they may feel subjectively extreme. If you are concerned about the possibility of experiencing either an hypertensive crisis or serotonin syndrome (although there should be no reason for it to happen if you don't have preexisting issues and are careful with interactions), have someone that has previously learned to tell actually dangerous symptoms apart from Ayahuasca effects. For example, while you could feel severely hyperthermic, a thermometer most likely will only show slightly elevated temperature.

This is important because calling for unnecessary medical assistance in the middle of an experience is something risky in itself. Everything possible should be done so one can be sure that a medical emergency is exceedingly unlikely, and if the perspective of one worries you (and may worry you during the trip), again have a sitter that has learned the basics about identifying when there's a reason to be concerned.