Ketamine also leads to problems with thinking, memory, and concentration.

[corpus callosum]

The clinical picture that longterm frequent ketamine use produces with respect to the urinary tract (especially the bladder) is very similar to a medical condition called interstitial cystitis.Heres an intersting MSc thesis rerlating to this:

http://etheses.whiterose.ac.uk/2104/1/Khurram_Shahzad_MSc_Thesis.pdf


Depending on the users intentions/pattern of us, I think that the dissociatives can be a very useful class of compounds due to the nature of the headspace they impart.IMO/E one can certainly go very far with them, and theres a 'therapeutic window' in which much good work can be done in terms of gaining insights into oneself.The emotional detachment they elicit can allow those shadier crannies of ones psyche to be inspected without evoking the emotional turmoil which the classic psychedelics are able/prone to evoke.

I also think that very infrequent use allows the positive aspects of the experience to remain evident.The thing that ketamine has in its favor, IMO, is the short duration of the experience when used IM.DXM is a longer haul and subjectively feels more toxic than K if you were to just have 1 dose of each (but not at the same time!).MXE is a smoother affair if you're within the therapeutic window than either K or DXM, and it has some additional opioid-like effects which to my mind make it the disso-of-choice if access to only one agent of the class were permitted.This, I think, is what makes it a riskier proposition than the others leading to injudicious patterns of use.

 

[daedaloops]

Not to drag this more off-topic but just wanted to agree with Hyperspace Fool that DXM can indeed take you to places that are very very similar to a deep aya experience. On lower doses DXM just enhances music and makes you feel like a robot, but on 3rd and 4th plateaus it's like, extremely vivid hallucinations about going to the strangest and coldest parts of the universe, impossible architectures and endless robotic fields, and the perspective feels like your eyes are hundreds of meters apart. There's very little awareness compared to aya, you have no memory of your life so it's not nearly as scary, in fact it's quite an addicting feeling to just float around in space thinking that it's always been like this.. But yeah otherwise it's like a very robotic and cold version of aya IMO.

Just wanted to put that out there, I think there's alot of interesting aspects on dissos but also alot of bad ones like addiction potential and toxicity.. So yeah be careful with these things.