I see chemicals as a species of sorts..same with plants..there is no "unnatural"..if there is a spirit of a plant, why not a spirit of a chemical?..same difference to me. Western scientists synthed DMT long before they ever discovered it in nature..even all the stuff mckenna was smoking back in the day was synthetic, he had nothing but good things to say.
The spirit of the mushrooms was sure as hell in those little psilocybin pills according to Maria Sabina.